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AG-1478

Catalog No. T2047   CAS 153436-53-4
Synonyms: AG1478, NSC 693255, Tyrphostin AG-1478

AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
AG-1478 Chemical Structure
AG-1478, CAS 153436-53-4
Pack Size Availability Price/USD Quantity
5 mg In stock $ 45.00
10 mg In stock $ 61.00
25 mg In stock $ 114.00
50 mg In stock $ 207.00
100 mg In stock $ 288.00
200 mg In stock $ 374.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.71%
Purity: 99.71%
Purity: 99.03%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.
Targets&IC50 EGFR:3 nM
Cell Research Cells are exposed to different concentrations of AG-1478 for 72 hours in 96-well plates. The effects of AG-1478 on cell growth are examined using an Alamar Blue assay. A 20-μL aliquot of Alamar Blue is added to each well, and its absorbance is determined using a Spectromax Scanning Micro plate Reader. The effects of AG-1478 are expressed as percentage of growth inhibition using untreated cells as the control (0% inhibition). Cellular DNA synthesis is determined using a [3H]thymidine incorporation assay. (Only for Reference)
Synonyms AG1478, NSC 693255, Tyrphostin AG-1478
Molecular Weight 315.75
Formula C16H14ClN3O2
CAS No. 153436-53-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 11 mg/mL (34.8 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 24 mg/mL (76 mM)

TargetMolReferences and Literature

1. Levitzki A, et al. Science, 1995, 267(5205), 1782-1788. 2. Han Y, et al. Cancer Res, 1996, 56(17), 3859-3861. 3. Eguchi S, et al. J Biol Chem, 1998, 273(15), 8890-8896. 4. Johns TG, et al. Proc Natl Acad Sci U S A, 2003, 100(26), 15871-15876. 5. Lee FT, et al. Clin Cancer Res, 2005, 11(19 Pt 2), 7080s-7086s. 6. Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215. 7. Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580. 8. Li S T, Young T H, Huang T W. Poly (ethylene-co-vinyl alcohol) is a suitable substrate for human olfactory neuroepithelial cell differentiation in vitro through a defined regulatory pathway[J]. Acta biomaterialia. 2018 Mar 1;68:204-213.

TargetMolCitations

1. Li S T, Young T H, Huang T W. Poly (ethylene-co-vinyl alcohol) is a suitable substrate for human olfactory neuroepithelial cell differentiation in vitro through a defined regulatory pathway. Acta Biomaterialia. 2018 Mar 1;68:204-213 2. Yao G, Wang X, Wang Y, et al. miR‑4792 regulates inflammatory responses in Cryptococcus neoformans‑infected microglia. International Journal of Molecular Medicine. 2021, 48(5): 1-15.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Kinase Inhibitor Library Inhibitor Library Anti-Prostate Cancer Compound Library Anti-Infection Compound Library Anti-Ovarian Cancer Compound Library Bioactive Compound Library

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Keywords

AG-1478 153436-53-4 Angiogenesis JAK/STAT signaling Microbiology/Virology Proteases/Proteasome Tyrosine Kinase/Adaptors HCV Protease Influenza Virus EGFR PDGFR HER diseases encephalomyocarditis HCV virus HER1 obesity AG1478 cardiovascular myocardial NSC 693255 injury ErbB-1 EMCV Tyrphostin AG-1478 Hepatitis C virus antiviral AG 1478 NSC693255 Tyrphostin AG 1478 Epidermal growth factor receptor inhibit Inhibitor cancer NSC-693255 chemotherapy Tyrphostin AG1478 inhibitor

 

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