antidepressant-like — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3886	Rosavin	Rosavidin	P450
	Rosavin (Rosavidin) has antidepressant and anxiolytic actions, helps balance all the neurotransmitters.		P450
T3856	Tenuifoliside A		ERK , Others
	Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB and MAPK pathways.		ERK , Others
T18918	Azure B	Azure B chloride	MAO , Monoamine Oxidase
	Azure B (Azure B chloride) is a cationic dye and the major metabolite of Methylene blue. Azure B is a selective, and reversible inhibitor of MAO-A (IC50s: 11 and 968 nM for recombinant human MAO-A and MAO-B).		MAO , Monoamine Oxidase
T5648	Purpurin	1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin	MAO , Antibacterial , Antibiotic , Antifungal
	Purpurin (Verantin) was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities.		MAO , Antibacterial , Antibiotic , Antifungal
T3933	Jatrorrhizine	Yatrorizine,neprotin	MAO , 5-HT Receptor , Antibacterial , AChE
	Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo...		MAO , 5-HT Receptor , Antibacterial , AChE
T39341	FCPR03		PDE
	FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr...		PDE
T16421	P-MPPI hydrochloride		5-HT Receptor
	p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.		5-HT Receptor
T21995	XAP044		GluR
	XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm[1].		GluR
T4912	Jatrorrhizine chloride	Yatrorhizine chloride,Neprotine chloride	Others , 5-HT Receptor , OCT , Antibacterial , AChE
	Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h...		Others , 5-HT Receptor , OCT , Antibacterial , AChE
T15795	Luzindole	N-0774	Melatonin Receptor , MT Receptor
	Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1...		Melatonin Receptor , MT Receptor
T19916	TRIM	1-(2-Trifluoromethylphenyl)imidazole	NOS
	TRIM (1-(2-Trifluoromethylphenyl)imidazole) is an inhibitor of nNOS.		NOS
T6714	URB-597	KDS-4103,FAAH Inhibitor II	Mitophagy , FAAH , Autophagy
	URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.		Mitophagy , FAAH , Autophagy
T7601L	Carbetocin acetate	Carbetocin acetate(37025-55-1 free base)	Oxytocin Receptor
	Carbetocin acetate is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.		Oxytocin Receptor
T9112	(-)-Perillaldehyde		AhR , ROS , Nrf2
	(-)-Perillaldehyde shows antibacterial activity.		AhR , ROS , Nrf2
T7601	Carbetocin		Oxytocin Receptor
	Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.		Oxytocin Receptor
T3698	Alpha-Asarone	α-Asarone,trans-Asarone	P450 , GABA Receptor , HMG-CoA Reductase
	alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice.		P450 , GABA Receptor , HMG-CoA Reductase
T61518	TAK-653		iGluR
	TAK-653, a selective positive allosteric modulator (PAM) of AMPA receptors exhibiting minimal agonistic activity, elicits an antidepressant-like response while maintaining a favorable safety profile in rat models.		iGluR
T5S2195	Sibiricose A5		Dehydrogenase
	Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia.		Dehydrogenase
T5S2204	Sibiricose A6		Antioxidant
	1. Sibiricose A6 displays antidepressant-like action, it may prevent or relieve depression. 2. Sibiricose A6 shows potent antioxidant activity.		Antioxidant
T23349	SF 11		Others
	SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist with IC50 of 199 nM. Antidepressant-like activity		Others