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URB-597

Catalog No. T6714 CAS 546141-08-6

Synonyms: FAAH Inhibitor II, KDS-4103

URB597 is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.

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URB-597, CAS 546141-08-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 34.00
10 mg	In stock	$ 55.00
25 mg	In stock	$ 122.00
50 mg	In stock	$ 198.00
100 mg	In stock	$ 328.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 97.84%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	URB597 is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
Targets&IC50	FAAH:4.6 nM
In vitro	URB597 binds in the hydrophobic pocket and catalytic core of FAAH that connects the active site residues to the membrane surface of FAAH. [1] URB597 inhibits FAAH activity in human liver microsomes with IC50 of 3 nM. [2] URB597 reduces the expression of the LPS-induced enzymes cyclo-oxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS2) in primary rat microglial cell, with a concomitant reduction in the release of the inflammatory mediators prostaglandin E2 (PGE2) and (NO) nitric oxide. [3] URB597 evokes Ca2+ entry in HEK293-F Cells transiently expressing human or rat TRPA1 gene. URB597 also activates Ca2+ entry in rat DRG neurons natively expressed TRPA1 channels. [4]
In vivo	URB597 inhibits [3H]anandamide hydrolysis in rat brain membranes with a parallel increase in brain anandamide, OEA, and PEA content by inhibition of FAAH. URB597 enhances the hypothermia effect induced by ethanolamide by inhibiting FAAH. [5] When delivered intraperitonealy (0.3 mg/kg) URB597 reduces allodynia and hyperalgesia through cannabinoid CB1 and CB2 receptor-mediated analgesia in rats with inflammatory pain. [6] URB597 reduces the reduction in body weight gain and sucrose intake induced by the chronic mild stress in rats through inhibition of brain FAAH activity. [7] URB597 could reverse most depressive-like symptoms induced by adolescent THC exposure in femal rats. [8]

Synonyms	FAAH Inhibitor II, KDS-4103
Molecular Weight	338.4
Formula	C20H22N2O3
CAS No.	546141-08-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: 5 mg/mL (14.77 mM)

DMSO: 68 mg/mL (200.94 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Mor M, et al. J Med Chem, 2004, 47(21), 41998-52008. 2. Piomelli D, et al. CNS Drug Rev, 2006, 12(1), 21-38. 3. Tham CS, et al. FEBS Lett, 2007, 581(16), 2899-2904. 4. Niforatos W, et al. Mol Pharmacol, 2007, 71(5), 1209-1216. 5. Fegley D, et al. J Pharmacol Exp Ther, 2005, 313(1), 352-358.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Preclinical Compound Library NO PAINS Compound Library Orally Active Compound Library Cuproptosis Compound Library Metabolism Compound Library Lipid Metabolism Compound Library Neuronal Signaling Compound Library Clinical Compound Library Anti-Obesity Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

URB-597 546141-08-6 Autophagy Metabolism Neuroscience Mitophagy FAAH Mitochondrial Autophagy bioavailable inhibit Fatty acid amide hydrolase KDS4103 FAAH Inhibitor II Antidepressant-like KDS-4103 Inhibitor Analgesic orally liver URB597 microsomes KDS 4103 URB 597 inhibitor

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