anti-vegf — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9928	Ranibizumab		VEGFR
	Ranibizumab is a humanized monoclonal antibody fragment designed to target and inhibit vascular endothelial growth factor (VEGF), including VEGF110, VEGF121, and VEGF165. Ranibizumab's ability to selectively target and n...		VEGFR
TN1557	Decursinol angelate		ERK , VEGFR , PKC , JNK
	Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion an...		ERK , VEGFR , PKC , JNK
T33701	NM-3	NM-3,isocoumarin,NM 3,Isocoumarin NM-3,NM3	Apoptosis , Reactive Oxygen Species
	NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular endothelial growth factor (VEGF), thereby inhibiting the p...		Apoptosis , Reactive Oxygen Species
T5429	Theaflavin 3,3'-digallate	8-Gingerol,TFDG	Virus Protease , Antioxidant , HIV Protease , HSV
	Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregul...		Virus Protease , Antioxidant , HIV Protease , HSV
T27028	CJ-3-60	CJ 3-60,CJ3-60,CJ-360,CJ360,CJ 360
	CJ-3-60, an anti-HIF-1alpha agent, inhibits HIF-1alpha and cellular VEGF proteins.
T12650	R916562		TAM Receptor
	R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.		TAM Receptor
T35492	(±)10(11)-DiHDPA
	(±)10(11)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid . It has been shown to inhibit VEGF-induced angiogenesis in mice and may have additional anti-inflammatory and anti-tumor effec...
TN3139	5α-Hydroxycostic acid	5alpha-Hydroxycostic acid	ERK , FAK , Phospholipase , NOS , Akt , Src
	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.		ERK , FAK , Phospholipase , NOS , Akt , Src
T10273	AhR modulator-1		Others
	AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrog...		Others
T80593	Brolucizumab	DLX1008,ESBA 1008,RTH258	VEGFR
	Brolucizumab (DLX1008) is a single-chain anti-VEGF-A antibody fragment exhibiting low picomolar affinity (K D = 1.05 pM), utilized for cancer research [1] [2].		VEGFR
T68935	BMS-645737
	BMS-645737 is an inhibitor of vascular endothelial growth factor (VEGF) receptor-2 and fibroblast growth factor (FGF) receptor-1. BMS-646737 has anti-angiogenic activity and was evaluated in nonclinical studies as a trea...
TN1874	Liriodendrin		ATPase , Potassium Channel , Prostaglandin Receptor
	Liriodendrin regulates lung inflammation, the phosphorylation of the NF-kB (p65) and expression of vascular endothelial growth factor (VEGF). Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities a...		ATPase , Potassium Channel , Prostaglandin Receptor
T76871	Navicixizumab
	Navicixizumab (OMP-305B83) is a bispecific anti- VEGF and anti- DLL4 inhibitory antibody. Navicixizumab can combine with Paclitaxel for cancer research. Navicixizumab can be used in the research of ovarian, primary peri...
TN4356	Jolkinolide A		Akt , STAT , mTOR
	Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly inhibited the proliferation and migration of HUVECs.		Akt , STAT , mTOR
T78064	Synstatin (92-119)	SSTN92-119	Integrin
	Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and attenuation of angiogenic growth factor activation, specific...		Integrin
T74118	Roxatidine
	Roxatidine, the active metabolite of Roxatidine acetate hydrochloride, serves as a histamine H2-receptor antagonist and exhibits anti-ulcer properties. It functions by suppressing the release of histamine, thereby inhibi...
T77108	Olinvacimab
	Olinvacimab (TTAC-0001), a fully human anti-VEGFR2 monoclonal antibody, demonstrates antiangiogenic activity by inhibiting VEGF binding to KDR, with a dissociation constant (K d) of 0.23 nM. It is utilized in research fo...
T71176	Atiprimod (free base)
	Atiprimod is an orally bioavailable small molecule belonging to the azaspirane class of cationic amphiphilic agents with anti-inflammatory, antineoplastic, and antiangiogenic properties. Atiprimod inhibits the phosphoryl...
T69599	ABT-510
	ABT-510 is synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascul...
T68324	KCN1
	KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF repo...