Powder: -20°C for 3 years | In solvent: -80°C for 1 year
R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis. |
Targets&IC50 | VEGFR2:24 nM, Axl:136 nM |
In vivo | Treatment with R916562 at dosages of 85 mg/kg or 125 mg/kg (administered orally twice daily for 21 days) leads to statistically significant tumor growth inhibitions of 69% and 83%, respectively. Additionally, R916562 achieves a 73% reduction in fibroblast growth factor-induced neovascularization in the mouse corneal micropocket assay at 100 mg/kg, and a 50% reduction at 50 mg/kg[1]. |
Molecular Weight | 536.09 |
Formula | C26H30ClN9S |
CAS No. | 1037798-41-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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R916562 1037798-41-6 Tyrosine Kinase/Adaptors TAM Receptor R 916562 R-916562 inhibitor inhibit