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Search Results for " alzheimer "

20

Compounds

Cat No. Product Name Synonyms Targets
TN1858 Leptomerine AChE
Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity.
T7829 FK962 Somatostatin
FK962 is an somatostatin release enhancer , exerts cognitive-enhancing actions.
TP1856 Colivelin Beta Amyloid , STAT
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
T7891 Ipidacrine NIK‐247 Others
Ipidacrine (NIK‐247) (NIK‐247) is an Antidementia Agent
T7905 PBD-150 Beta Amyloid
PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)
T14199 ALZ-801 Valiltramiprosate Beta Amyloid
ALZ-801 is an orally available, valine-conjugated prodrug of tramiprosate. ALZ-801 is an advanced and markedly improved candidate for the treatment of Alzheimer's disease. ALZ-801 is a potent and orally available small-m...
T26324 VU0071063 VU 0071063,VU-0071063 Potassium Channel
VU0071063 is a Kir6.2/SUR1 activator.
T9694 Emraclidine CVL-231 AChR
Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator and can be used in neurological diseases studies.
T16481 PF-04995274 5-HT Receptor
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has a...
T6483 EHT 1864 EHT 1864 2HCl Rho , Ras
EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).
T1993 J-147 J147 Epigenetic Reader Domain , Dopamine Receptor , Monoamine Oxidase
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate...
T14782 Brilaroxazine RP5063 Dopamine Receptor , 5-HT Receptor
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-...
T9611 PF-04802367 GSK-3
PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and ...
T2607 MSDC 0160 CAY10415,Mitoglitazone,MSDC0160,MSDC-0160 Others , IGF-1R , Mitochondrial Metabolism
MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.
T5678 Lazabemide hydrochloride N-(2-Aminoethyl)-5-chlor-2-pyridincarbox MAO , Monoamine Oxidase
Lazabemide hydrochloride (N-(2-Aminoethyl)-5-chlor-2-pyridincarbox) is a reversible and selective mao-b inhibitor(Ki:7.9nM).
T1884 CX516 Ampakine CX516,BDP 12,Ampalex GluR , iGluR
CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
T5470 LAZABEMIDE Ro 19-6327 MAO , Monoamine Oxidase
Lazabemide (Ro 19-6327) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively).
TN1653 Fustin ERK , Beta Amyloid , AChR
Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
T12525 Pozanicline dihydrochloride ABT-089 dihydrochloride AChR
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of nicotinic acetylcholine receptor (nAChR) (Ki = 16.7 nM)
T20172L Kyotorphin acetate Endogenous Metabolite , Antibacterial
Kyotorphin acetate is an endogenous peptide with analgesia activity and can be used as a biomarker of Alzheimer disease.
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