20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1858 | Leptomerine | AChE | |
Leptomerine (IC50 = 2.5 mM) shows potent anticholinesterasic activity. | |||
T7829 | FK962 | Somatostatin | |
FK962 is an somatostatin release enhancer , exerts cognitive-enhancing actions. | |||
TP1856 | Colivelin | Beta Amyloid , STAT | |
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN). | |||
T7891 | Ipidacrine | NIK‐247 | Others |
Ipidacrine (NIK‐247) (NIK‐247) is an Antidementia Agent | |||
T7905 | PBD-150 | Beta Amyloid | |
PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM) | |||
T14199 | ALZ-801 | Valiltramiprosate | Beta Amyloid |
ALZ-801 is an orally available, valine-conjugated prodrug of tramiprosate. ALZ-801 is an advanced and markedly improved candidate for the treatment of Alzheimer's disease. ALZ-801 is a potent and orally available small-m... | |||
T26324 | VU0071063 | VU 0071063,VU-0071063 | Potassium Channel |
VU0071063 is a Kir6.2/SUR1 activator. | |||
T9694 | Emraclidine | CVL-231 | AChR |
Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator and can be used in neurological diseases studies. | |||
T16481 | PF-04995274 | 5-HT Receptor | |
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has a... | |||
T6483 | EHT 1864 | EHT 1864 2HCl | Rho , Ras |
EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM). | |||
T1993 | J-147 | J147 | Epigenetic Reader Domain , Dopamine Receptor , Monoamine Oxidase |
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate... | |||
T14782 | Brilaroxazine | RP5063 | Dopamine Receptor , 5-HT Receptor |
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-... | |||
T9611 | PF-04802367 | GSK-3 | |
PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and ... | |||
T2607 | MSDC 0160 | CAY10415,Mitoglitazone,MSDC0160,MSDC-0160 | Others , IGF-1R , Mitochondrial Metabolism |
MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease. | |||
T5678 | Lazabemide hydrochloride | N-(2-Aminoethyl)-5-chlor-2-pyridincarbox | MAO , Monoamine Oxidase |
Lazabemide hydrochloride (N-(2-Aminoethyl)-5-chlor-2-pyridincarbox) is a reversible and selective mao-b inhibitor(Ki:7.9nM). | |||
T1884 | CX516 | Ampakine CX516,BDP 12,Ampalex | GluR , iGluR |
CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). | |||
T5470 | LAZABEMIDE | Ro 19-6327 | MAO , Monoamine Oxidase |
Lazabemide (Ro 19-6327) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively). | |||
TN1653 | Fustin | ERK , Beta Amyloid , AChR | |
Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death. | |||
T12525 | Pozanicline dihydrochloride | ABT-089 dihydrochloride | AChR |
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of nicotinic acetylcholine receptor (nAChR) (Ki = 16.7 nM) | |||
T20172L | Kyotorphin acetate | Endogenous Metabolite , Antibacterial | |
Kyotorphin acetate is an endogenous peptide with analgesia activity and can be used as a biomarker of Alzheimer disease. |