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Ipidacrine

Catalog No. T7891   CAS 62732-44-9
Synonyms: NIK‐247

Ipidacrine (NIK‐247) (NIK‐247) is an Antidementia Agent

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Ipidacrine Chemical Structure
Ipidacrine, CAS 62732-44-9
Pack Size Availability Price/USD Quantity
25 mg In stock $ 29.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Purity: 97.73%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ipidacrine (NIK‐247) (NIK‐247) is an Antidementia Agent
In vivo A single oral administration of ipidacrine (0.3 and 1 mg/kg) reduced the increased total latency induced by scopolamine in this task.?The repeated administration of ipidacrine (1 mg/kg) of once a day for 5 successive days reduced the increased total latency induced by scopolamine to the levels of the saline-treated control rats in this task.Ipidacrine was rapidly taken up into the brain within 5 min. Moreover, higher drug levels were observed mainly in the cortex and hippocampus, which both play important roles in learning and memory.?Thus, a previous study together with this investigation indicate that ipidacrine improves amnesia which consists of the impairment of the working and reference memory in various animal models, suggesting that ipidacrine is a useful candidate for the therapy of patients with Alzheimer's disease[1].
Synonyms NIK‐247
Molecular Weight 188.27
Formula C12H16N2
CAS No. 62732-44-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (53.11 mM)

TargetMolReferences and Literature

1. Onodera K , Kojima J , Wachi M . Ipidacrine (NIK-247), a novel antidementia, rapidly enters the brain and improves scopolamine-induced amnesia in rats during the Morris water maze task[J]. Japanese Journal of Psychopharmacology, 1998, 18(2):33-37. 2. Kojima J , Onodera K , Ozeki M , et al. Ipidacrine (NIK7): A Review of Multiple Mechanisms as an Antidementia Agent[J]. CNS Drug Reviews, 2006, 4(3):247-259.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library ReFRAME Related Library Bioactive Compounds Library Max Human Metabolite Library NO PAINS Compound Library

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Keywords

Ipidacrine 62732-44-9 Others inhibit NIK‐247 cholinesterase nootropic Inhibitor Cholinesterase (ChE) Alzheimer disease inhibitor

 

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