Powder: -20°C for 3 years
In solvent: -80°C for 2 years
LAZABEMIDE(Ro 19-6327) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively).
Description | LAZABEMIDE(Ro 19-6327) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively). |
Targets&IC50 | MAO-B:30 nM |
In vitro | LAZABEMIDE is selective, high-affinity ligands for enzymes.?KD and Bmax values for 3H-Ro 41 1049 in rat cerebral cortex were 10.7 nM and 7.38 pmol/mg protein, respectively, and for 3H-Ro 19 6327 were 18.4 nM and 3.45 pmol/mg protein, respectively.?In accordance with their potencies as enzyme inhibitors, binding to MAO-A and MAO-B was competitively inhibited by clorgyline (IC50 = 1.4 nM) and L-deprenyl (selegiline;?IC50 = 8.0 nM), respectively[1]. |
In vivo | Lazabemide is a reversible inhibitor of monoamine oxidase B (MAO-B) with IC50 values of 0.48 and 1.5 μM measured in platelets of human subjects ages 19-36 and 60-78, respectively[2]. |
Synonyms | Ro 19-6327, 拉扎贝胺 |
Molecular Weight | 199.64 |
Formula | C8H10ClN3O |
CAS No. | 103878-84-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 34 mg/mL (170.31 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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LAZABEMIDE 103878-84-8 代谢 神经科学 MAO Monoamine Oxidase parkinson inhibit radical generation ichemia alzheimer′s Ro 19-6327 smoking cessation Inhibitor DOPAC disease inhibitor