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LAZABEMIDE

Catalog No. T5470 CAS 103878-84-8

Synonyms: Ro 19-6327, 拉扎贝胺

LAZABEMIDE(Ro 19-6327) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively).

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LAZABEMIDE, CAS 103878-84-8

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Purity: 98%

Biological Description

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Description	LAZABEMIDE(Ro 19-6327) is selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively).
Targets&IC50	MAO-B:30 nM
In vitro	LAZABEMIDE is selective, high-affinity ligands for enzymes.?KD and Bmax values for 3H-Ro 41 1049 in rat cerebral cortex were 10.7 nM and 7.38 pmol/mg protein, respectively, and for 3H-Ro 19 6327 were 18.4 nM and 3.45 pmol/mg protein, respectively.?In accordance with their potencies as enzyme inhibitors, binding to MAO-A and MAO-B was competitively inhibited by clorgyline (IC50 = 1.4 nM) and L-deprenyl (selegiline;?IC50 = 8.0 nM), respectively[1].
In vivo	Lazabemide is a reversible inhibitor of monoamine oxidase B (MAO-B) with IC50 values of 0.48 and 1.5 μM measured in platelets of human subjects ages 19-36 and 60-78, respectively[2].

Synonyms	Ro 19-6327, 拉扎贝胺
Molecular Weight	199.64
Formula	C8H10ClN3O
CAS No.	103878-84-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 34 mg/mL (170.31 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Saura J, et al. Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J Neurosci. 1992 May;12(5):1977-99. 2. Holford N H , Guentert T W , Dingemanse J , et al. Pharmacodynamics of lazabemide, a reversible and selective inhibitor of monoamine oxidase B.[J]. British Journal of Clinical Pharmacology, 1994, 37(6):553-557.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LAZABEMIDE 103878-84-8 代谢神经科学 MAO Monoamine Oxidase parkinson inhibit radical generation ichemia alzheimer′s Ro 19-6327 smoking cessation Inhibitor DOPAC disease inhibitor

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