pten — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7012	VO-Ohpic trihydrate	VO-Ohpic	PTEN , Autophagy
	VO-Ohpic trihydrate (VO-Ohpic) is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.		PTEN , Autophagy
T7953	BpV(HOpic)	bpV (HOpic)	PTEN
	BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM).		PTEN
T3780	Oroxin B	Hypocretin-2	Apoptosis , PTEN , Antioxidant , PI3K , Autophagy
	Oroxin B (Hypocretin-2) has antioxidant activity.		Apoptosis , PTEN , Antioxidant , PI3K , Autophagy
TN1362	Afzelin	Kaempferol-3-O-rhamnoside	PTEN , p38 MAPK , TNF , Mitochondrial Metabolism , Antibacterial , Prostaglandin Receptor , Autophagy
	Afzelin (Kaempferol-3-O-rhamnoside) has several cellular activities such as DNA-protective, antibacterial, antioxidant, and anti-inflammatory as well as UV-absorbing activity and may protect human skin from UVB-induced d...
T6S2116	Ginkgolic acid C17:1		Phosphatase , PTEN
	1. Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes.		Phosphatase , PTEN
T6303	CCT128930		Akt , PKA , S6 Kinase , Autophagy
	CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.		Akt , PKA , S6 Kinase , Autophagy
T6667	SF1670	PTP CD45 Inhibitor,PTPase CD45 Inhibitor	Phosphatase , PTEN , Autophagy
	SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.		Phosphatase , PTEN , Autophagy
T1952	MK-2206 dihydrochloride	MK-2206 2HCl	Apoptosis , Akt , Autophagy
	MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and selective potency. MK-2206 dihydrochloride exhibits antitumor a...		Apoptosis , Akt , Autophagy
T14511	BAY1082439		Apoptosis , PI3K
	BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2]. Additionally, BAY1082439 is effective against mutated forms o...		Apoptosis , PI3K
T6303L	CCT128930 hydrochloride	CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis , Akt , PKA , mTOR , Autophagy
	CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28...		Apoptosis , Akt , PKA , mTOR , Autophagy
T5747	ISOBERGAPTEN		Others
	ISOBERGAPTEN is a plant growth regulating substance, it is the principal constituents responsible for the antimycobacterial activity of the roots of Heracleum maximum; it may form an important class of natural defensive ...		Others
T2S1702	(5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one	(5R)-trans-1,7-diphenyl-5-hydroxy-6-hept,5-Hydroxy-1,7-diphenyl-6-hepten-3-one	Antioxidant
	(5R,6E)-5-Hydroxy-1,7-diphenyl-6-hepten-3-one ((5R)-trans-1,7-diphenyl-5-hydroxy-6-hept) has antioxidant activity.		Antioxidant
T2143	Bergapten	5-Methoxypsoralen	P450 , Autophagy
	Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.		P450 , Autophagy
T2852	Citropten	Limettin,Citroptene,Limetin,5, 7-Dimethoxycoumarin,5,7-Dimethoxycoumarin	Others
	Citropten (Limetin) is a natural organic compound and is found in the essential oils of citrus such as lime, lemon, and bergamot.		Others
T77548	(6Z)-7-Phenyl-7-(3-Pyridinyl)-6-Heptenoic Acid
	(6Z)-7-Phenyl-7-(3-Pyridinyl)-6-Heptenoic Acid is a derivative of 7-Phenyl-7-(3-Pyridyl) -6-Heptenoic Acid that can be used in biological research.
TN1345	8-Hydroxybergapten		Others
	8-Hydroxybergapten may have anti-wrinkle activity.		Others
T4115	Auraptene	7-geranyloxycoumarin	MMP , BACE
	Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits le...		MMP , BACE
TN2523	1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one		Others
	1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one is a natural product of Alpinia, Zingiberaceae. The catalog number is TN2523 and the CAS number is 87095-77-0. 1,7-Diphenyl-5-hydroxy-4,6-hepten-3-one can be used as a reference st...		Others
T64309	Isometheptene mucate
	Isometheptene mucate is a sympathomimetic agent, an indirectly acting adrenergic receptor agonist, which can be used in the study of migraine.
T81790	Miptenalimab	BI-754111
	Miptenalimab (BI-754111) is an anti-human LAG-3 antibody with a dissociation constant (K D) of 88.6 nM for h LAG-3, effectively blocking the interaction between LAG-3 and its ligand MHC-II [1].