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Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 68.00 | |
1 g | In stock | $ 117.00 | |
5 g | In stock | $ 473.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication. |
In vitro | In C57BL/6J mice induced with acetaminophen (APAP), Bergapten exhibits antioxidant activity and mitigates hepatotoxicity. |
In vivo | In both tamoxifen-sensitive and -resistant breast cancer cells, Bergapten eliminates ERα and reprograms membrane signaling targeted at ERα, thereby enhancing the potential for cell mitosis. |
Cell Research | 5-Methoxypsoralen (5-MOP) is dissolved in DMSO and stored, and then diluted with appropriate medium (final DMSO <0.1%) before use[1]. The human colon adenocarcinoma cell line (COLO 205, from a 70-year-old male Caucasian) sre placed into 75-cm2 tissue culture flasks and grown in RPMI1640 medium, supplemented with 10% fetal bovine serum, containing penicillin and streptomycin (100 Ig/mL) and 1 mM glutamine, at 37°C in a humidified atmosphere of 5% CO2 and 95% O2. The human stomach adenocarcinoma cell line are placed into 75-cm2 tissue culture flasks and grown in RPMI 1640 medium, supplemented with 10% fetal bovine serum, containing penicillin and streptomycin (100 Ig/mL) and 1 mM glutamine, at 37°C in a humidified atmosphere of 5% CO2 and 95% O2. SC-M1 and COLO 205 cells are treated with different concentrations of 5-MOP (0.05, 0.5, 5, 10, 25 and 50 mM) and incubated for 72 h for the dose-effect study of 5-MOP on NAT activity. To determine the time-course effect of 0.5 mM 5-MOP on NAT activity, the cells are incubated at 37AC and harvested at 12, 24, 48 and 72 h, respectively. 5-MOP is dissolved in DMSO and the final concentration of vehicle is <0.1%. Only DMSO (solvent) is added for the control regimen[1]. |
Source |
Synonyms | 5-Methoxypsoralen |
Molecular Weight | 216.19 |
Formula | C12H8O4 |
CAS No. | 484-20-8 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 5 mg/mL (23.12 mM), The compound is unstable in solution. Please use soon.
You can also refer to dose conversion for different animals. More
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Bergapten 484-20-8 Autophagy Metabolism P450 inhibit Inhibitor CYPs 5-Methoxypsoralen Cytochrome P450 inhibitor