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Auraptene

Catalog No. T4115 CAS 495-02-3

Synonyms: 橙皮油内酯, 橙皮油素, 7-geranyloxycoumarin

Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.1 When examined for its potential use in Alzheimer's disease treatment, auraptene was shown to inhibit β-secretase (BACE1) activity with an IC50 value of 345.1 μM.

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Auraptene, CAS 495-02-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

BACE1:345.1 μM.

Synonyms	橙皮油内酯, 橙皮油素, 7-geranyloxycoumarin
Molecular Weight	298.382
Formula	C19H22O3
CAS No.	495-02-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: >20 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Murakami, A.,Nakamura, Y.,Tanaka, T., et al. Suppression by citrus auraptene of phorbol ester- and endotoxin-induced inflammatory responses: Role of attenuation of leukocyte activation. Carcinogenesis 21(10), 1843-1850 (2000). 2. Krishnan, P.,Yan, K.J.,Windler, D.,et al.Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats.BMC Cancer9,(2009). 3. Takeda, K.,Utsunomiya, H.,Kakiuchi, S.,et al. Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils.J.Oleo Sci.56(5),253-260(2007). 4. Furukawa, Y.,Watanabe, S.,Okuyama, S., et al. Neurotrophic effect of Citrus auraptene: Neuritogenic activity in PC12 cells.International Journal of Molecular Sciences 13,5338-5347(2012). 5. Sahebkar, A.Citrus auraptene: A potential multifunctional therapeutic agent for nonalcoholic fatty liver disease.Ann.Hepatol.10(4),575-577(2011).

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cardiovascular Disease Compound Library Traditional Chinese Medicine Monomer Library Antibiotics Library Inhibitor Library Anti-Gastroenteritis Natural Product Library Natural Product Library for HTS Anti-Tumor Natural Product Library Immunology/Inflammation Compound Library Anti-Alzheimer's Disease Compound Library

Related Products

Related compounds with same targets

Lanabecestat Putraflavone Kushenol C Anatabine Bavachromene Epiberberine chloride PF-06751979 BACE1-IN-5

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Keywords

Auraptene 495-02-3 蛋白酶体神经科学 BACE MMP inhibit Inhibitor Matrix metalloproteinases 7-geranyloxycoumarin inhibitor

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