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Auraptene

Catalog No. T4115 CAS 495-02-3

Synonyms: 7-geranyloxycoumarin

Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.1 When examined for its potential use in Alzheimer's disease treatment, auraptene was shown to inhibit β-secretase (BACE1) activity with an IC50 value of 345.1 μM.

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Auraptene, CAS 495-02-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 39.00
25 mg	In stock	$ 59.00
50 mg	In stock	$ 76.00
100 mg	In stock	$ 139.00
500 mg	In stock	$ 339.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

Purity: 99.17%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.1 When examined for its potential use in Alzheimer's disease treatment, auraptene was shown to inhibit β-secretase (BACE1) activity with an IC50 value of 345.1 μM.
Targets&IC50	BACE1:345.1 μM.
Source	Natural Products > Rutaceae > Poncirus

Synonyms	7-geranyloxycoumarin
Molecular Weight	298.38
Formula	C19H22O3
CAS No.	495-02-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (167.56 mM)

References and Literature

1. Murakami, A.,Nakamura, Y.,Tanaka, T., et al. Suppression by citrus auraptene of phorbol ester- and endotoxin-induced inflammatory responses: Role of attenuation of leukocyte activation. Carcinogenesis 21(10), 1843-1850 (2000). 2. Krishnan, P.,Yan, K.J.,Windler, D.,et al.Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats.BMC Cancer9,(2009). 3. Takeda, K.,Utsunomiya, H.,Kakiuchi, S.,et al. Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils.J.Oleo Sci.56(5),253-260(2007). 4. Furukawa, Y.,Watanabe, S.,Okuyama, S., et al. Neurotrophic effect of Citrus auraptene: Neuritogenic activity in PC12 cells.International Journal of Molecular Sciences 13,5338-5347(2012). 5. Sahebkar, A.Citrus auraptene: A potential multifunctional therapeutic agent for nonalcoholic fatty liver disease.Ann.Hepatol.10(4),575-577(2011).

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Traditional Chinese Medicine Monomer Library Anti-Hypertension Compound Library Human Endogenous Metabolite Compound Library Plus Natural Product Library for HTS NO PAINS Compound Library Target-Focused Phenotypic Screening Library Anti-Tumor Natural Product Library Bioactive Compounds Library Max

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Keywords

Auraptene 495-02-3 Neuroscience Proteases/Proteasome BACE MMP inhibit Inhibitor Matrix metalloproteinases 7-geranyloxycoumarin inhibitor

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