PI3K/Akt/mTOR signaling PTEN SF1670


Catalog No. T6667   CAS 345630-40-2
Synonyms: PTPase CD45 Inhibitor, PTP CD45 Inhibitor, PTPase CD45 Inhibitor PTP CD45 Inhibitor

SF1670 is a specific PTEN inhibitor with IC50 of 2 μM.

SF1670, CAS 345630-40-2
Pack Size Availability Price/USD Quantity
2 mg In stock 56.00
5 mg In stock 101.00
10 mg In stock 150.00
25 mg In stock 325.00
50 mg In stock 600.00
100 mg In stock 960.00
1 mL * 10 mM (in DMSO) In stock 110.00
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Biological Description
Chemical Properties
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Description SF1670 is a specific PTEN inhibitor with IC50 of 2 μM.
Targets&IC50 PTEN : ic50 2μM,  
In vivo Pretreatment of SF1670 (500 nM i.v.) augments bacteria-killing capability in neutropenic mice in both peritonitis and bacterial pneumonia, and decreases the mortality of neutropenia-related pneumonia. [2]
Kinase Assay PTEN Inhibition Assay: To determine the dose response of potential PTEN inhibitors, doses of test compounds ranging from 1 nM to 250 uM (final reaction mix concentrations) are evaluated in the general PTEN inhibition assay. To obtain performed IC50 data, two separate rounds of the dose response assay are performed. In the first round, PTEN activity is tested in the presence of inhibitor at 10 fold serial dilutions ranging from 1 nM to 250 uM. Once the concentration range is determined, at which PTEN activity changes dramatically, two additional concentration data points within this range are added and the PTEN inhibition assay is then rerun for the second round. The PTEN inhibition IC50 is presented as the inhibitor concentration at which 50% of the PTEN activity. When the assay was run on multiple occasions and gave slightly different IC50 then those are reported as a range of IC50 found.
Cell Research
Cells are plated into 96-well plates in RPMI 1640 medium supplemented with 10% FBS and incubated overnight at 37°C. in an incubator containing an atmosphere of 5% CO2. The following day, the medium is replaced and cells are starved by placing in 100 uL of serum-free medium for 3 hours. Serially diluted test compounds are added to the wells and incubated with the cells for 2 hours at 37°C. Compounds are tested in a range from 1 mM to 0.1 nM depending on solubility. MTT is added to the wells at a final concentration of 5 μg/ml and incubated with the cells for 3 more hours. At the end of the incubation, the medium is aspirated and the MTT stain in the cells is dissolved by the addition of 100 μL DMSO. Optical density of each well is then measured at 570 nm using a SpectroMax Plus spectrophotometric plate reader. The IC50 determination from the data was made using Prism software.(Only for Reference)
Cell lines: Human brain endothelial cells (HBEC), human prostate cancer cells (PC-3) and human non-small cell lung cancer cells (H1299)
Animal Research
Animal Model: Neutropenic mice
Synonyms PTPase CD45 Inhibitor , PTP CD45 Inhibitor , PTPase CD45 Inhibitor PTP CD45 Inhibitor
Purity 98.54%
Molecular Weight 307.34
Formula C19H17NO3
CAS No. 345630-40-2


0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 30.7 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Garlich JR, et al. PCT/US2005/011626. 2. Li Y, et al. Blood. 2011, 17(24), 6702-6713. 3. Montales MT, et al. Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells. Genes Nutr. 2015 Nov;10(6):49.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Anti-infection Compound Library PI3K-AKT-mTOR Compound Library Anti-Metabolism Disease Compound Library Phosphatase Inhibitor Library

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