Search Result

Search Results for " pk1 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T6835	Fenoldopam mesylate	Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526	Dopamine Receptor
	Fenoldopam mesylate (Corlopam mesylate) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.		Dopamine Receptor
T39195	YM-244769 dihydrochloride		Calcium Channel
	YM-244769 dihydrochloride is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 dihydrochloride has efficient protective effects on neurons and kidneys.		Calcium Channel
T9888	YM-244769	3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-	Calcium Channel
	YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 has efficient protective effec...		Calcium Channel
T12731	RIPK1-IN-7		RIP kinase
	RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.		RIP kinase
T4459	PK11000		DNA Alkylator/Crosslinker
	PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.		DNA Alkylator/Crosslinker
T72033	PCDPK1/TgCDPK1-IN-3		Parasite
	CpCDPK1/TgCDPK1-IN-3 is a dual inhibitor of CpCDPK1 and TgCDPK1 with an IC50 of 0.003 µM for CpCDPK1 and 0.0036 µM for TgCDPK1. CpCDPK1/TgCDPK1-IN-3 can be used to study infections associated with diseases such as Toxopl...		Parasite
T7897	PK150		Others , Antibacterial
	PK150 shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations.		Others , Antibacterial
T72081	CpCDPK1/TgCDPK1-IN-2		Parasite
	CpCDPK1/TgCDPK1-IN-2 is a dual inhibitor of CpCDPK1 and TgCDPK1 with IC50 values of 12 and 5 nM for CpCDPK1 and TgCDPK1, respectively.CpCDPK1/TgCDPK1-IN-2 can be used in the study of diseases associated with infection of...		Parasite
T9017	HPK1-IN-2	Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2,HPK1-IN-2	Others , FLT , Src
	HPK1-IN-2 (Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2) is a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1; IC50<0.05 μΜ). It also...		Others , FLT , Src
T11943	MAPK13-IN-1		p38 MAPK
	MAPK13-IN-1 is a potent MAPK13 (p38δ) inhibitor (IC50: 620 nM).		p38 MAPK
T78605	CpCDPK1/TgCDPK1-IN-1		Bcr-Abl , Src
	CpCDPK1/TgCDPK1-IN-1 is a potent dual inhibitor of CpCDPK1 and TgCDPK1, inhibits Abl and Src, and has antiparasitic activity for the study of Toxoplasma infections and cryptosporidiosis.		Bcr-Abl , Src
T63055	RIPK1-IN-9		RIP kinase
	RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respectively.		RIP kinase
T40350	HPK1-IN-4	HPK1-IN-4	MAPK
	HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.		MAPK
T78268	Anti-Mouse NK1.1 Antibody (PK136)
	Anti-Mouse NK1.1 Antibody (PK136) is an IgG2a class antibody of murine origin targeting NK1.1, which eliminates NK1.1 and NK1.1NKT cells and inhibits NK1.1 signaling in peripheral blood, spleen, and lung tissues, and can...
T7703	PK11007		Reactive Oxygen Species , p53
	PK11007 is an anti-p53 drug.		Reactive Oxygen Species , p53
T9470	HPK1-IN-7		MAPK
	HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).		MAPK
T12730	RIPK1-IN-4		RIP kinase
	RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).		RIP kinase
T63541	HPK1-IN-27
	HPK1-IN-27 is a potent inhibitor of HPK1. Among them, MAP4K1, also known as hematopoietic progenitor kinase 1 (HPK1), is a member of the germinal center kinase family and is a serine/threonine kinase. HPK1-IN-27 has show...
T62927	HPK1-IN-22
	HPK1-IN-22 (compound ZYF0033) is a haematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of less than 10 nM for MBP protein-based phosphorylation inhibition. HPK1-IN-22 reduces phosphorylation of SLP76 (serine...
T64064	RIPK1-IN-10
	RIPK1-IN-10 is a potent inhibitor of RIPK1.
T73149	HPK1-IN-33
	HPK1-IN-33 (compound 21), a Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor, exhibits a high potency with a K_i of 1.7 nM. It effectively inhibits IL-2 production, demonstrating EC_50 values of 286 nM in Jurkat WT cel...
T16547	PK14105		Others
	PK14105 has been evaluated biologically as a potential radioligand for positron emission tomography (PET) studies targeting peripheral benzodiazepine binding sites (PBBS) receptors. When administered to rats with unilate...		Others
T73186	HPK1-IN-31
	HPK1-IN-31 inhibitor with an IC 50 value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunotherapy .
T60973	HPK1-IN-24
	HPK1-IN-24 (example 51) has potential to be used in the cancer research which is an inhibitor of hematopoietic progenitor kinase 1 (HPK1) (Ki = 100 nM) [1].
T79790	ALPK1-IN-3		NF-κB
	ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-induced acute kidney injury [1].		NF-κB
T62315	HPK1-IN-30
	HPK1-IN-30 is a potent inhibitor of HPK1. HPK1-IN-30 has potential for cancer disease research.
T61733	HPK1-IN-25
	HPK1-IN-25 (example 94), an inhibitor of hematopoietic progenitor kinase 1 (HPK1), demonstrates enzymatic activity with an IC50 value of 129 nM, indicating its potential utility in cancer research [1].
T61887	RIPK1-IN-13
	RIPK1-IN-13 (Compound 8) is an effective RIPK1 inhibitor (IC50=1139 nM). By inhibiting RIPK1, RIPK1-IN-13 can block the activation of necrotic apoptosis pathway. RIPK1-IN-13 has research potential in inflammatory disease...
T40188	HPK1-IN-20	HPK1-IN-20
	HPK1-IN-19 is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1).
T39709	HPK1-IN-19	HPK1-IN-19
	HPK1-IN-19 is an inhibitor of hematopoietic progenitor kinase 1 (HPK1).
T63469	RIPK1-IN-8
	RIPK1-IN-8 is an aminoimidazolopyridine and is a selective and potent inhibitor of RIPK1 (IC50: 4 nM).RIPK1-IN-8 has research potential in inflammatory diseases.
T62162	ALPK1-IN-2
	ALPK1-IN-2 is a potent inhibitor of ALPK1 (α-kinase 1) (IC50: 95 nM). ALPK1-IN-2 inhibits NF-κB (IC50: 1.31 μM).
T63270	HPK1-IN-29
	HPK1-IN-29 is a potent inhibitor of HPK1, in which hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the activation response of dendritic cells (DCs), T cells and B cells. HPK1-IN-29 is able to enhance ...
T72052	HPK1-IN-34
	HPK1-IN-34 is a Hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 of <100 nM.
T81269	RIPK1-IN-16		RIP kinase
	RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo. It shields mice from TNF-induced systemic inflammatory response syndrome...		RIP kinase
T72036	HPK1-IN-36		Others
	HPK1-IN-36 (compound 2) is a potent inhibitor of hematopoietic progenitor kinase 1 (HPK1), demonstrating an inhibitory concentration 50 (IC50) of 0.5 nM [1].		Others
T62632	HPK1-IN-21
	HPK1-IN-21 is a potent, orally active HPK1 kinase inhibitor with a Ki value of 0.8 nM.
T63176	ALPK1-IN-1
	ALPK1-IN-1 (Compound A001) is a potent inhibitor of alpha-kinase 1 (ALPK1). ALPK1 is an intracytoplasmic serine/threonine protein kinase that plays an important role in activating the innate immune response to bacteria b...
T12729	RIPK1-IN-3		Others
	RIPK1-IN-3 is a RIPK1 inhibitor, with anti-inflammatory proprieties.		Others
T62742	HPK1-IN-11
	HPK1-IN-11 is a potent HPK1 inhibitor. HPK1-IN-11 has potential for the study of HPK1-related diseases.
T79071	HPK1 antagonist-1
	HPK1 antagonist-1 (I-792) is an inhibitor targeting HPK1, with potential applications in cancer and immune disease research [1].
T38599	HPK1-IN-8	HPK1-IN-8
	HPK1-IN-8 is an allosteric inhibitor that selectively targets the inactive conformation of full-length HPK1.
T79787	HPK1-IN-37
	HPK1-IN-37 (compound A85), with an IC50 value of 3.7 nM, is a potent inhibitor of HPK1. It is suitable for research purposes involving HPK1-associated diseases and disorders, notably cancers [1].
T79788	HPK1-IN-38
	HPK1-IN-38 (compound 15) is an inhibitor of MAP4K1/HPK1, suitable for research into disorders related to HPK1 [1].
T62629	HPK1-IN-13
	HPK1-IN-13 is a potent inhibitor of HPK1. HPK1-IN-12 has potential for the study of HPK1-related diseases.
T62547	HPK1-IN-17
	HPK1-IN-17 is a selective and potent inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPK1) is a member of the MAP4Ks family and was originally cloned from hematopoietic progenitor cells. HPK1-IN-17 can be used to s...
T29258	(R)-N-Desmethyl PK11195	(R)-N-Desmethyl PK 11195,(R)-N-Desmethyl PK-11195,(R)-N Desmethyl PK11195,(R) N-Desmethyl PK11195
	(R)-N-Desmethyl PK11195 is a precursor for (R)-[N-Methyl-11C-]PK11195.
T61449	HPK1-IN-18
	HPK1-IN-18 is a highly effective and specific HPK1 inhibitor. HPK1, a MAP kinase kinase kinase kinases (MAP4K) member, was initially isolated from hematopoietic progenitor cells. This compound, known as HPK1-IN-18, is va...
T81268	RIPK1-IN-17		RIP kinase
	RIPK1/3-IN-1 (Compound 10) is a selective inhibitor of both RIPK1 and RIPK3, effectively preventing necroptosis by blocking the phosphorylation of RIPK1, RIPK3, and MLKL [1].		RIP kinase
T63670	HPK1-IN-9
	HPK1-IN-9 is a potent HPK1 inhibitor. HPK1 is a serine/threonine protein kinase cloned from hematopoietic progenitor cells and is a member of the MAP4K family of mammalian Ste-20-related protein kinases. HPK1-IN-10 has p...

Compounds

Fenoldopam mesylate

T6835

Synonym: Fenoldopam methanesulfonate,SKF-82526 mesylate,Corlopam mesylate,mesylate,SKF 82526

Target: Dopamine Receptor

YM-244769 dihydrochloride

T39195

Synonym:

Target: Calcium Channel

YM-244769

T9888

Synonym: 3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-

Target: Calcium Channel

Target: DNA Alkylator/Crosslinker

Target: Others, Antibacterial

Synonym: Thieno[2,3-b]pyridin-6(7H)-one, 4-amino-5-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-HPK1-IN-2,HPK1-IN-2

Target: Others, FLT, Src

Anti-Mouse NK1.1 Antibody (PK136)

Target: Reactive Oxygen Species, p53

(R)-N-Desmethyl PK11195

T29258

Synonym: (R)-N-Desmethyl PK 11195,(R)-N-Desmethyl PK-11195,(R)-N Desmethyl PK11195,(R) N-Desmethyl PK11195

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02945	Prokineticin 1/EG-VEGF Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	EG-VEGF, also known as prokineticin-1, is a member of the AVIT (prokineticin) family. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. EG-VEG...
TMPY-04765	PKLR Protein, Human, Recombinant (His)	Human	E. coli
	Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pat...
TMPY-04430	P38 gamma/MAPK12 Protein, Human, Recombinant	Human	Baculovirus Insect Cells
	p38 gamma/MAPK12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.1 kDa and the accession number is P53778.
TMPY-04531	P38 delta/MAPK13 Protein, Human, Recombinant (GST), Activated in vitro	Human	Baculovirus Insect Cells
	p38 delta/MAPK13 Protein, Human, Recombinant (GST), Activated in vitro is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68.4 kDa and the accession number is O15264.
TMPH-03631	CDPK1 Protein, Toxoplasma gondii, Recombinant (His)	Toxoplasma gondii	E. coli
	N/A. CDPK1 Protein, Toxoplasma gondii, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 63.3 kDa and the accession number is Q9BJF5.
TMPY-04478	IP6K1/IHPK1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	IP6K1 (Inositol Hexakisphosphate Kinase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. IHPK1 is an inositol hexaphosphate kinase (IHPK) protein that belongs to the inositol phosph...
TMPH-01639	MAPK1IP1L Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	N/A. MAPK1IP1L Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q8NDC0.
TMPY-04429	P38 gamma/MAPK12 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.8 kDa and the accession number is P53778.
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold fun...
TMPH-02964	UMP-CMP kinase/CMPK1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. A...
TMPH-02007	RIPK1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	RIPK1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.4 kDa and the accession number is Q13546.
TMPY-04551	P38 delta/MAPK13 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	p38 delta/MAPK13 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68.4 kDa and the accession number is O15264.
TMPH-00922	ALPK1 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus Insect Cells
	ALPK1 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus.
TMPY-04773	TPK1 Protein, Human, Recombinant (His)	Human	E. coli
	Thiamine pyrophosphokinase (TPK) produces thiamine pyrophosphate, a cofactor for a number of enzymes, including pyruvate dehydrogenase and 2-ketoglutarate dehydrogenase. Episodic encephalopathy type thiamine metabolism d...
TMPY-04480	UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), re...
TMPY-04567	SRPK1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	Serine / threonine-protein kinase SRPK1, also known as SFRS protein kinase 1, Serine/arginine-rich protein-specific kinase 1, SR-protein-specific kinase 1 and SRPK1, is a cytoplasm and nucleus protein that belongs to the...
TMPY-04417	DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)	Human	Baculovirus Insect Cells
	Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK...
TMPH-02786	MAPK14 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	MAPK14 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 48.6 kDa and the accession number is P47811.