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RIPK1-IN-4

Catalog No. T12730 CAS 1481641-08-0

RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

RIPK1-IN-4, CAS 1481641-08-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 151.00
5 mg	In stock	$ 317.00
10 mg	In stock	$ 497.00
25 mg	In stock	$ 896.00
50 mg	In stock	$ 1,487.00
100 mg	In stock	$ 1,995.00
1 mL * 10 mM (in DMSO)	In stock	$ 283.00

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Purity: 99.66%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).
Targets&IC50	RIP1:16 nM , ADP-Glo:10 nM

Molecular Weight	401.47
Formula	C23H23N5O2
CAS No.	1481641-08-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 225.0 mg/mL (560.5 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Anti-Ovarian Cancer Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Eclitasertib RIPA-56 GSK547 HS-1371 GSK-872 Necrostatin-5 GSK3145095 RIPK1-IN-4

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RIPK1-IN-4 1481641-08-0 Apoptosis NF-Κb RIP kinase RIPK1IN4 RIPK-1-IN-4 RIPK1 IN 4 Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.