nsclc — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN2108	Protohypericin		Others
	Protohypericin, a naphthodianthrone derivative found in the plant Hypericum perforatum, exhibits photocytotoxicity and is utilized in tumor necrosis targeted radiotherapy through its radioiodinated form.		Others
T9460	IMDK		PI3K
	iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors withou...		PI3K
T40254	MRTX-1719		Histone Methyltransferase
	MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells.		Histone Methyltransferase
T6455	CP-91149		Phosphorylase
	CP-91149 is a selective glycogen phosphorylase (GP) inhibitor with IC50 of 0.13 μM in the presence of glucose, 5- to 10-fold less potent in the absence of glucose.		Phosphorylase
T9929	Ramucirumab		VEGFR
	Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors.		VEGFR
T10777	CG347B		HDAC
	CG347B is a selective inhibitor of HDAC6.		HDAC
T8732	CTPI-2		Others , Mitochondrial Metabolism
	CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 ha...		Others , Mitochondrial Metabolism
T4903	Heptadecanoic acid		Others , Endogenous Metabolite
	Heptadecanoic acid is a fatty acid of exogenous (primarily ruminant) origin. Many "odd" length long chain amino acids are derived from the consumption of dairy fats (milk and meat). Heptadecanoic acid constitutes 0.61% o...		Others , Endogenous Metabolite
TN1153	Polyporenic acid C		Apoptosis , PARP , Caspase , PI3K
	Polyporenic acid C shows inhibitory activity against human collagenase.		Apoptosis , PARP , Caspase , PI3K
T6734	WZ8040		EGFR
	WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).		EGFR
T11224	Rineterkib	ERK-IN-1	ERK , Raf
	Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.		ERK , Raf
T13176	TNO155	Batoprotafib	Phosphatase
	TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplastic activity.		Phosphatase
T12695	RBN-2397		PARP
	RBN-2397 is a potent, selective and orally active accross species NAD+ competitive PARP7 inhibitor with IC50 less than 3 nM.		PARP
T5414	Glumetinib	SCC244	c-Met/HGFR
	Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).		c-Met/HGFR
T8684	Sotorasib	AMG-510	Ras
	Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib ...		Ras
T22254	Alflutinib	AST2818,ASK120067	EGFR , P450
	Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.		EGFR , P450
T22318	Taletrectinib	DS-6051b,AB-106	Trk receptor , ROS , ROS Kinase
	Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.		Trk receptor , ROS , ROS Kinase
T8151	Mobocertinib	tak788	EGFR
	Mobocertinib (tak788) is a potent inhibitor of epidermal growth factor receptor (EGFR) and an antineoplastic agent		EGFR
T39275	Befotertinib	D-0316,Befotertinib	EGFR
	Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.		EGFR
T8327	ONO-7475		Trk receptor , TAM Receptor
	ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase		Trk receptor , TAM Receptor