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ONO-7475

Catalog No. T8327 CAS 1646839-59-9

ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase

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ONO-7475, CAS 1646839-59-9

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Purity: 98%

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Description	ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
Targets&IC50	MER tyrosine kinase:1.0 nM (IC50), Axl:0.7 nM (IC50)
In vitro	ONO-7475 sensitized AXL-overexpressing?EGFR-mutant NSCLC cells to the EGFR-TKIs osimertinib and dacomitinib. In addition, ONO-7475 suppressed the emergence and maintenance of EGFR-TKI-tolerant cells[2].
In vivo	Mice fed a diet containing ONO-7475 exhibited significantly longer survival and, interestingly, blocked leukemia cell infiltration in the liver. In summary, ONO-7475 effectively kills acute myeloid leukemia cells?in vitro?and?in vivo?by mechanisms that involve disruption of diverse survival and proliferation pathways[1].
Cell Research	Cell Line:High AXL-expressing cell: PC-9,HCC4011,H1975, PC-9KGR cells. Low AXL-expressing cell: HCC827, HCC4006, and H3255 cells. Concentration:0.0001 μM; 0.001 μM; 0.01 μM; 0.1 μM; 1 μM. Incubation Time:72 hours[1].

Molecular Weight	562.582
Formula	C32H26N4O6
CAS No.	1646839-59-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (177.76 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ruvolo PP, et al. Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms.Haematologica. 2017 Dec;102(12):2048-2057. 2. Okura N, et al. ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non-Small Lung Cancer.Clin Cancer Res. 2020 Jan 17.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Covalent Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Bioactive Compound Library Tyrosine Kinase Inhibitor Library

Related Products

Related compounds with same targets

DS-1205 ONO-7475 2-D08 NPS-1034 Pralatrexate S49076 HCl S49076 UNC 569 hydrochloride

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ONO-7475 1646839-59-9 蛋白酪氨酸激酶 TAM Receptor Trk receptor lung tumor leukemia inhibit solid Trk Receptor tolerant cancer Mer Tropomyosin related kinase receptor NSCLC EGFR ONO 7475 Tyro3 advanced ONO7475 mutunt Inhibitor Axl TKI acute metastatic inhibitor

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