Powder: -20°C for 3 years
In solvent: -80°C for 2 years
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
Description | ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase |
Targets&IC50 | MER tyrosine kinase:1.0 nM (IC50), Axl:0.7 nM (IC50) |
In vitro | ONO-7475 sensitized AXL-overexpressing?EGFR-mutant NSCLC cells to the EGFR-TKIs osimertinib and dacomitinib. In addition, ONO-7475 suppressed the emergence and maintenance of EGFR-TKI-tolerant cells[2]. |
In vivo | Mice fed a diet containing ONO-7475 exhibited significantly longer survival and, interestingly, blocked leukemia cell infiltration in the liver. In summary, ONO-7475 effectively kills acute myeloid leukemia cells?in vitro?and?in vivo?by mechanisms that involve disruption of diverse survival and proliferation pathways[1]. |
Cell Research | Cell Line:High AXL-expressing cell: PC-9,HCC4011,H1975, PC-9KGR cells. Low AXL-expressing cell: HCC827, HCC4006, and H3255 cells. Concentration:0.0001 μM; 0.001 μM; 0.01 μM; 0.1 μM; 1 μM. Incubation Time:72 hours[1]. |
Molecular Weight | 562.582 |
Formula | C32H26N4O6 |
CAS No. | 1646839-59-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 100 mg/mL (177.76 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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ONO-7475 1646839-59-9 蛋白酪氨酸激酶 TAM Receptor Trk receptor lung tumor leukemia inhibit solid Trk Receptor tolerant cancer Mer Tropomyosin related kinase receptor NSCLC EGFR ONO 7475 Tyro3 advanced ONO7475 mutunt Inhibitor Axl TKI acute metastatic inhibitor