ml-7 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3050	ML-7 hydrochloride	ML-7 HCl	Serine/threonin kinase , Myosin , YAP , PKA , PKC
	ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and...		Serine/threonin kinase , Myosin , YAP , PKA , PKC
T33451	ML 7	ML7,ML-7
	ML 7 is an inhibitor of myosin light chain kinase that protects cardiac function from ischemia/reperfusion (I/R) injury.
T8954	ML179	ML-179	Others
	ML179 is a potent and selective inverse agonist of liver receptor homolog-1 (LRH1, NR5A2) with IC50 of 320 nM.		Others
TN3049	4-Methoxycinnamyl alcohol		Others
	4-Methoxycinnamyl alcohol showed toxicity to MCF-7, HeLa and DU145 cancer cell lines with IC50 values of 14.24, 7.82 and 22.10 μg/mL, respectively. 4-Methoxycinnamyl alcohol was isolated from Foeniculum vulgare. 4-Methox...		Others
T6010	Idarubicin hydrochloride	Idamycin,4-demethoxydaunorubicin (NSC256439, 4-DMDR) HCl,4-Demethoxydaunorubicin hydrochloride,Idarubicin HCl,Zavedos	Topoisomerase , Antibacterial , Autophagy , Antifungal
	Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).		Topoisomerase , Antibacterial , Autophagy , Antifungal
T2S1682	Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside	Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose,pinocembrin-7-o-3-o-galloyl-4-6-hexahydroxydiphenoyl-beta-d-glucoside	Amylase
	Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can moderately inhibit α-amylase activity, with the IC50 value of 0.03 umol/ml.		Amylase
T2785	4-Methylherniarin	7-Methoxy-4-methylcoumarin	Others , Antibacterial
	4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label, it displays good activity against B. subtilis.		Others , Antibacterial
T8724	6-Methoxydihydrosanguinarine		Others
	6-Methoxydihydrosanguinarine is a natural product. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial act...		Others
TN2030	P-Hydroxyphenethyl trans-ferulate		5-HT Receptor
	P-Hydroxyphenethyl trans-ferulate exhibits affinity toward 5-HT(7) receptors in a competitive binding assay. P-Hydroxyphenethyl trans-ferulate can double quinone reductase specific activity in Hepa 1c1c7 cells at a level...		5-HT Receptor
TN1291	7,3',4'-Tri-O-methylluteolin	5-Hydroxy-3',4',7-trimethoxyflavone	TNF , COX , Interleukin
	7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC value of 19.0 ug/ml		TNF , COX , Interleukin
T5S2358	Dehydrocorydaline	Dehydrocorydalin,13-Methylpalmatine	BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
	1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...		BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
T2S1865	Octyl gallate	Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8	Antioxidant , Influenza Virus , Reactive Oxygen Species , Antibacterial , Antifungal , HSV
	1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, ...
T13551	Araliadiol		Others
	Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cell growth (IC50: 6.41 µg/mL).		Others
T36141	Boscalid		Mitochondrial Metabolism
	Boscalid is a broad-spectrum carboxamide fungicide that inhibits fungal respiration by binding to the ubiquinone site of mitochondrial complex II/succinate dehydrogenase.1It suppresses mycelial growth ofS. minorby 87 to ...		Mitochondrial Metabolism
T38915	Antibacterial agent 32
	Antibacterial agent 32 exhibits potent antimicrobial activity against E. coli strains NCTC 13351, M 50, and 7 MP, with minimum inhibitory concentration (MIC) values of 1 mcg/mL, 2 mcg/mL, and 8 mcg/mL, respectively (WO20...
TN3825	Demethylmurrayanine		Others
	O-Demethylmurrayanine and clausine D exhibit strong cytotoxicity against MCF-7 and SMMC-7721 with IC50 values in the range 2.63-7.59 ug/ml.		Others
T81540	Parthenosin	Quercetin 3-O-β-D-glucuronide butyl ester
	Parthenosin (Quercetin 3-O-β-D-glucuronide butyl ester), a flavonoid derived from the aerial parts of Calligoum polygonoides, exhibits cytotoxic properties with IC50 values of 60.46 μg/mL for HepG2 and 61.4 μg/mL for MCF...
T67909	TAK1 inhibitor	compound 13a	Topoisomerase
	TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively. TAK1 inhibitor showed good antibacterial activity with microphones ranging fro...		Topoisomerase
T62240	Sirt1/2-IN-1
	Sirt1/2-IN-1 (Compound 7) is an inhibitor of SIRT1 and SIRT2 and is capable of acting on SIRT1 (IC50: 1.81 μg/mL), SIRT2 (IC50: 2.10 μg/mL) and SIRT3 (IC50: 20.5 μg/mL) and has α-microtubulin hyperacetylation activity ( ...
T75701	8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside
	8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside (Compound 3), a natural product isolated from Bidens bipinnata, exhibits a 22% inhibition against α-amylase at a concentration of 0.556 mg/mL [1].