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6-Methoxydihydrosanguinarine

Catalog No. T8724 CAS 72401-54-8

6-Methoxydihydrosanguinarine is a natural product. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) ranging from1.9 to 3.9 microg/ml

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6-Methoxydihydrosanguinarine Chemical Structure

6-Methoxydihydrosanguinarine, CAS 72401-54-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 139.00
2 mg	In stock	$ 188.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 428.00
25 mg	In stock	$ 698.00
50 mg	In stock	$ 968.00
100 mg	In stock	$ 1,280.00

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Purity: 99.81%

Purity: 99.75%

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Description	6-Methoxydihydrosanguinarine is a natural product. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) ranging from1.9 to 3.9 microg/ml
Targets&IC50	SF-268 cells:0.54 μM (IC50), MCF-7 cells:0.61 μM (IC50)
In vivo	6-methoxydihydrosanguinarine (6ME), a benzophenanthridine alkaloid isolated from Hylomecon species, may have potential as a chemotherapeutic agent.??6ME inhibits the growth of HepG2 cells in a concentration- and time-dependent manner (IC50=3.8+/-0.2 microM following 6 h incubation).?Treatment of HepG2 cells with 6ME resulted in the release of mitochondrial cytochrome c followed by the activation of caspase proteases, and subsequent proteolytic cleavage of poly(ADP-ribose) polymerase.?6ME increased the expression of p53 and bax and decreased the expression of bcl-2.?The cytotoxic effect of 6ME is mediated by the time-dependent generation of reactive oxygen species.?Preincubation of HepG2 cells with vitamin C decreased the expression of p53 and bax and inhibited the release of cytochrome c, activation of downstream caspase and the cleavage of poly(ADP-ribose) polymerase, thus inhibiting the apoptosis inducing effect of 6ME
Source	Natural Products > Papaveraceae > Hylomecon

Molecular Weight	363.36
Formula	C21H17NO5
CAS No.	72401-54-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (137.6 mM)

References and Literature

1. Yin H Q , Kim Y H , Moon C K , et al. Reactive oxygen species-mediated induction of apoptosis by a plant alkaloid 6-methoxydihydrosanguinarine in HepG2 cells[J]. Biochemical Pharmacology, 2005, 70(2):242-248. 2. Zou HL, et al. Alkaloids from Macleaya cordata and their cytotoxicity assay. Zhongguo Zhong Yao Za Zhi. 2015 Feb;40(3):458-62.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Bioactive Compound Library Anti-Infection Compound Library Natural Product Library for HTS Bioactive Compounds Library Max Natural Product Library RO5 Drug-like Natural Product Library Anti-infective Natural Product Library Alkaloid Natural Product Library Anti-Bacterial Compound Library

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Keywords

6-Methoxydihydrosanguinarine 72401-54-8 Others cancer SF-268 6 Methoxydihydrosanguinarine inhibit Inhibitor lkaloid 6Methoxydihydrosanguinarine MCF-7 inhibitor

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