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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3183 | SAX-187 | WAY 181187,WAY181187 | 5-HT Receptor |
SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor. | |||
T6920 | ON123300 | FGFR , c-RET , JAK , CDK , PDGFR , Src , AMPK | |
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM). | |||
T13007 | ST1936 oxalate | 5-HT Receptor | |
ST1936 oxalate is a selective, nanomolar affinity agonist of 5-HT6 receptor(Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively). | |||
T6196 | PP1 | EI 275,AGL 1872 | Apoptosis , EGFR , Bcr-Abl , Src , c-Kit |
PP1 (AGL 1872), a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively. | |||
T61360 | ARN25068 | GSK-3 , DYRK , Microtubule Associated , Src | |
ARN25068 is a potent inhibitor of GSK-3β, FYN, and DYRK1A protein kinases, exerting its activity in the sub-micromolar range. This compound effectively addresses tau hyperphosphorylation [1]. | |||
T6266 | PP2 | AGL 1879,AG 1879,AGL 1879 | EGFR , Tyrosine Kinases , JAK , Src |
PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2. | |||
T6997 | SU6656 | FAK , Akt , Src | |
SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively. | |||
T3935 | 1-Naphthyl PP1 | 1-NA-PP 1 | Src |
1-Naphthyl PP1 (1-NA-PP 1) is a selective src inhibitor(v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively) | |||
T6078 | Saracatinib | AZD0530 | EGFR , Src , BTK , Autophagy |
Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes. | |||
T23396 | ST1936 | ST 1936 oxalate | 5-HT Receptor |
ST1936 (ST 1936 oxalate) is a selective and potent 5-HT6 receptor agonist that inhibits human 5-HT6, 5-HT7, and 5-HT2B receptors, and stimulates cAMP, Ca2+, ERK1/2, and Fyn kinases through the complete activation of the ... | |||
T6093 | AZD-7762 | AZD7762 | Chk |
AZD-7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. | |||
T6277 | Doramapimod | BIRB 796 | Raf , p38 MAPK , Autophagy |
Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70. | |||
T7371 | 1-Naphthyl PP1 hydrochloride | 1-NA-PP 1 hydrochloride | Src |
1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases v-Src | |||
T4263 | BAY 61-3606 | Syk inhibitor IV | Apoptosis , Syk |
BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. | |||
T2153 | 1-NM-PP1 | PP1 Analog II,1 nM-PP1 | Serine/threonin kinase , CDK , Src |
1-NM-PP1 (PP1 Analog II) is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. | |||
T16364 | Infigratinib phosphate | NVP-BGJ398 phosphate,BGJ-398 phosphate | FGFR |
Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively). | |||
T38965 | EPQpYEEIPIYL | ||
EPQpYEEIPIYL, a phosphopeptide, is a ligand for the Src homology 2 (SH2) domain. It activates members of the Src family, such as Lck, Hck, and Fyn, through the binding interaction with SH2 domains. | |||
T71819 | RK-20448 | ||
RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259 | |||
T13157L | TG 100801 Hydrochloride | VEGFR | |
TG 100801 Hydrochloride is a prodrug to treat age-related macular degeneration. TG 100572 is a inhibitor of multi-targeted kinase(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PD... | |||
T13156 | TG 100572 | VEGFR | |
TG 100572 is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck,... |