Search Result

Search Results for " flk1 "

Targets

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T3980	Su1498	Tyrphostin SU 1498,AG 1498	VEGFR
	Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1,...		VEGFR
T3569	SU5214	SU 5214	VEGFR , Tyrosinase
	SU5214 is a modulator of tyrosine kinase signal transduction.		VEGFR , Tyrosinase
T3566	SU5205	SU 5205	VEGFR
	SU5205 is a VEGFR2 inhibitor.		VEGFR
T2496	(Z)-Semaxinib	SU5416	VEGFR
	(Z)-Semaxinib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor (IC50: 1.23 μM), 20-fold more selective for VEGFR over PDGFRβ, no inhibition for FGFR, InsR, and EGFR. (Z)-Semaxinib is a quinolone derivative w...		VEGFR
T2500	Cediranib	AZD2171,NSC-732208	VEGFR , FLT , PDGFR , c-Kit , Autophagy
	Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit...		VEGFR , FLT , PDGFR , c-Kit , Autophagy
T7394	Toceranib Phosphate	SU11654 phosphate,PHA 291639 phosphate	VEGFR , Tyrosinase , PDGFR , c-Kit
	Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR		VEGFR , Tyrosinase , PDGFR , c-Kit
T13178	Toceranib	PHA 291639E,SU11654	VEGFR , PDGFR , c-Kit
	Toceranib (PHA 291639E) phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively), has antitu...		VEGFR , PDGFR , c-Kit
T13238	Tyrphostin AG1433	SU1433,AG1433	VEGFR , PDGFR
	Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).		VEGFR , PDGFR
T5466	Tyrosine kinase-IN-1		VEGFR , FGFR , FLT , PDGFR
	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）		VEGFR , FGFR , FLT , PDGFR
T37079	VEGFR2 Kinase Inhibitor II
	Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms...
T2576	Brivanib (alaninate)	BMS-582664,Brivanib Alaninate	VEGFR , FGFR , Autophagy
	Brivanib Alaninate (BMS-582664) is the alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosi...		VEGFR , FGFR , Autophagy
T35570	Chiauranib	CS2164	c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
	Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-...		c-Fms , VEGFR , FLT , PDGFR , c-Kit , Aurora Kinase
T2514	Linifanib	ABT-869,RG3635,AL-39324	Apoptosis , c-Fms , VEGFR , FLT , CSF-1R , PDGFR , c-Kit , Autophagy
	Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: 66 nM). Linifanib may exhibit potent antiprolife...
T6720	Vatalanib dihydrochloride	CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride	Apoptosis , VEGFR , PDGFR
	Vatalanib dihydrochloride (PTK787 dihydrochloride)(IC50=37 nM) is an inhibitor of VEGFR2/KDR. It exhibits less effective against VEGFR1/Flt-1 and 18-fold against VEGFR3/Flt-4.		Apoptosis , VEGFR , PDGFR
T2116	AEE788	NVP-AEE 788	Apoptosis , EGFR , c-Fms , FLT , Bcr-Abl
	AEE788 (NVP-AEE 788) has been used in trials studying the treatment of Cancer, Glioblastoma Multiforme, and Brain and Central Nervous System Tumors.		Apoptosis , EGFR , c-Fms , FLT , Bcr-Abl
T2624	OSI-930	OSI 930	Apoptosis , c-Fms , Raf , VEGFR , FLT , CSF-1R , Src , c-Kit
	OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel growth (angiogenesis) in tumors.
T2288L	Motesanib Diphosphate	Motesanib,AMG 706	VEGFR , c-Kit
	Motesanib Diphosphate (AMG 706) is the orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity.		VEGFR , c-Kit
T1452	Axitinib	AG-013736	VEGFR , PDGFR , c-Kit
	Axitinib (AG-013736) is an orally bioavailable tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.7, 1.6 nM for VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFRβ, respectively.		VEGFR , PDGFR , c-Kit
T16750	Rigosertib	ON-01910	Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
	Rigosertib (ON-01910) is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kina...		Apoptosis , FLT , PLK , PI3K , Bcr-Abl , CDK , PDGFR , Src
T5818	Rigosertib sodium	Rigosertib,Estybon,ON-01910	Apoptosis , PLK , PI3K
	Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.		Apoptosis , PLK , PI3K
T6070	(E/Z)-Rigosertib sodium	(E/Z) ON-01910 sodium	PLK
	ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidativ...		PLK
T23504	VEGFR-IN-1	VEGFR Tyrosine Kinase Inhibitor II	Others
	VEGFR inhibitor		Others
T2500L	Cediranib maleate	AZD-2171,Recentin,AZD2171,AZD2171 maleate,AZD 2171
	Cediranib is a potent and selective inhibitor of VEGF with antineoplastic activities. It inhibits all three vascular endothelial growth factor receptor (VEGF-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, an...

Compounds

Su1498

T3980

Synonym: Tyrphostin SU 1498,AG 1498

Target: VEGFR, Tyrosinase

Synonym: AZD2171,NSC-732208

Target: VEGFR, FLT, PDGFR, c-Kit, Autophagy

Toceranib Phosphate

T7394

Synonym: SU11654 phosphate,PHA 291639 phosphate

Target: VEGFR, Tyrosinase, PDGFR, c-Kit

Toceranib

T13178

Synonym: PHA 291639E,SU11654

Target: VEGFR, PDGFR, c-Kit

Tyrphostin AG1433

T13238

Synonym: SU1433,AG1433

Target: VEGFR, FGFR, FLT, PDGFR

VEGFR2 Kinase Inhibitor II

Synonym: BMS-582664,Brivanib Alaninate

Target: VEGFR, FGFR, Autophagy

Chiauranib

T35570

Synonym: CS2164

Target: c-Fms, VEGFR, FLT, PDGFR, c-Kit, Aurora Kinase

Linifanib

T2514

Synonym: ABT-869,RG3635,AL-39324

Target: Apoptosis, c-Fms, VEGFR, FLT, CSF-1R, PDGFR, c-Kit, Autophagy

Vatalanib dihydrochloride

T6720

Synonym: CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride

Target: Apoptosis, VEGFR, PDGFR

AEE788

T2116

Synonym: NVP-AEE 788

Target: Apoptosis, EGFR, c-Fms, FLT, Bcr-Abl

OSI-930

T2624

Synonym: OSI 930

Target: Apoptosis, c-Fms, Raf, VEGFR, FLT, CSF-1R, Src, c-Kit

Motesanib Diphosphate

T2288L

Synonym: Motesanib,AMG 706

Target: VEGFR, PDGFR, c-Kit

Rigosertib

T16750

Synonym: ON-01910

Target: Apoptosis, FLT, PLK, PI3K, Bcr-Abl, CDK, PDGFR, Src

Rigosertib sodium

T5818

Synonym: Rigosertib,Estybon,ON-01910

Target: Apoptosis, PLK, PI3K

(E/Z)-Rigosertib sodium

T6070

Synonym: (E/Z) ON-01910 sodium

Target: PLK

VEGFR-IN-1

T23504

Synonym: VEGFR Tyrosine Kinase Inhibitor II

Target: Others

Cediranib maleate

T2500L

Synonym: AZD-2171,Recentin,AZD2171,AZD2171 maleate,AZD 2171

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02361	VEGFR2/KDR Protein, Human, Recombinant (His)	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.6 kDa and the accession number is P35968-1.
TMPY-04796	VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His)	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.8 kDa and the accession number is P35968-1.
TMPY-05610	VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 86.5 kDa and the accession number is P35968-1.
TMPY-04940	VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.6 kDa and the accession number is P35968-1.
TMPY-04802	VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc)	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.4 kDa and the accession number is P35968-1.
TMPK-00454	VEGFR2/KDR Protein, Human, Recombinant (His & Avi)	Human	HEK293 Cells
	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migratio...
TMPK-00645	VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)	Rhesus	HEK293 Cells
	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migratio...
TMPY-01044	VEGFR2/KDR Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 109 kDa and the accession number is P35968-1.
TMPY-05657	VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and the accession number is P35968-1.
TMPY-04530	VEGFR2/KDR Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	VEGFR2/KDR Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.3 kDa and the accession number is P35968-1.
TMPY-04795	VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His)	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.9 kDa and the accession number is P35968-1.
TMPY-04794	VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and the accession number is P35968-1.
TMPY-02858	VEGFR2/KDR Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	VEGFR2/KDR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110 kDa and the accession number is P35918.
TMPY-04924	VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated	Mouse	HEK293 Cells
	VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.5 kDa and the accession number is P35918-1.
TMPY-02736	VEGFR2/KDR Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	VEGFR2/KDR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.5 kDa and the accession number is P35918-1.
TMPJ-00593	VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 110-140 KDa and the accession number is AAI31823.1.
TMPJ-00414	VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 120-150 KDa and the accession number is P35968.