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Toceranib

Toceranib
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Purity:97.14%
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Toceranib

Catalog No. T13178Cas No. 356068-94-5
Toceranib (PHA 291639E) phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively), has antitumor and antiangiogenic activity.
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Pack SizePriceAvailabilityQuantity
10 mg$39In Stock
25 mg$59In Stock
50 mg$80In Stock
100 mg$118In Stock
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Product Introduction

Bioactivity
Description
Toceranib (PHA 291639E) phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively), has antitumor and antiangiogenic activity.
In vivo
Administration of toceranib significantly decreased the number and percentage of Treg in the peripheral blood of dogs with cancer. Dogs receiving toceranib and CYC demonstrated a significant increase in serum concentrations of IFN-γ, which was inversely correlated with Treg numbers after 6 weeks of combination treatment[1].
AliasPHA 291639E, SU11654
Chemical Properties
Molecular Weight396.46
FormulaC22H25FN4O2
Cas No.356068-94-5
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 2.4 mg/mL (6.05 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5223 mL12.6116 mL25.2232 mL126.1161 mL
5 mM0.5045 mL2.5223 mL5.0446 mL25.2232 mL

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