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Tyrphostin AG1433

Catalog No. T13238 CAS 168835-90-3

Synonyms: SU1433, AG1433

Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).

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Tyrphostin AG1433, CAS 168835-90-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
2 mg	In stock	$ 74.00
5 mg	In stock	$ 122.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 353.00
50 mg	In stock	$ 538.00
100 mg	In stock	$ 778.00
500 mg	In stock	$ 1,590.00
1 mL * 10 mM (in DMSO)	In stock	$ 133.00

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Purity: 97.51%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).
Targets&IC50	PDGFRβ:5 μM, FLK1:9.3 μM
In vitro	In glioblastoma cells, Tyrphostin AG1433 (0.1-100 μM; 72 hours; GB8B cells) treatment induces moderate cytotoxicity [1].
In vivo	Tyrphostin AG1433 is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day-old chicken embryos, and prevents the formation of new yessels under the pellets[2].

Synonyms	SU1433, AG1433
Molecular Weight	266.29
Formula	C16H14N2O2
CAS No.	168835-90-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 62.5 mg/mL (234.71 mM), Sonification is recommended.

References and Literature

1. Serban F, et al. Silencing of epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1 (ELTD1) via siRNA-induced cell death in glioblastoma. J Immunoassay Immunochem. 2017;38(1):21-33. 2. Strawn LM, et al. Flk-1 as a target for tumor growth inhibition. Cancer Res. 1996 Aug 1;56(15):3540-5. 3. Kim TS, et al. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech. 2010 Nov-Dec;3(11-12):752-62. 4. Kroll J, et al. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J Biol Chem. 1997 Dec 19;272(51):32521-7.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Lung Cancer Compound Library Anti-Prostate Cancer Compound Library Anti-Pancreatic Cancer Compound Library Bioactive Compounds Library Max Anti-Breast Cancer Compound Library Anti-Colorectal Cancer Compound Library Anti-Cardiovascular Disease Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tyrphostin AG1433 168835-90-3 Angiogenesis Tyrosine Kinase/Adaptors VEGFR PDGFR cytotoxicity PDGFRβ Tyrphostin AG-1433 kinases Vascular endothelial growth factor receptor SU 1433 SU1433 Tyrphostin AG 1433 Platelet-derived growth factor receptor AG1433 AG-1433 angiogenesis,tyrosine inhibit AG 1433 VEGFR-2 Inhibitor ATM SU-1433 inhibitor

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