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XL 999

Name: XL 999
Brand: TargetMol
SKU: T5466
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5466Cas No. 705946-27-6

Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor that acts on KDR, Flt-1, FGFR1, and PDGFRα with IC50 values of 4 nM, 20 nM, 4 nM, and 2 nM, respectively.

XL 999

🥰Excellent

Purity: 99.55%

Catalog No. T5466Cas No. 705946-27-6

Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor that acts on KDR, Flt-1, FGFR1, and PDGFRα with IC50 values of 4 nM, 20 nM, 4 nM, and 2 nM, respectively.

Pack Size	Price	Availability
2 mg	$37	In Stock
5 mg	$56	In Stock
10 mg	$98	In Stock
25 mg	$197	In Stock
50 mg	$297	In Stock
100 mg	$428	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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Batch Information

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Purity:99.55%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor that acts on KDR, Flt-1, FGFR1, and PDGFRα with IC50 values of 4 nM, 20 nM, 4 nM, and 2 nM, respectively.
Targets&IC50	KDR:20 nM , FLK1:4 nM , PDGFRα:4 nM , FGFR1:2 nM
In vivo	Tyrosine kinase-IN-1 demonstrates a reasonable pharmacokinetic profile [AUC(0–∞)=1.9, t1/2=4.6 h] and possesses favorable oral bioavailability (F=63%) in rats.

Chemical Properties

Molecular Weight	445.53
Formula	C₂₆H₂₈FN₅O
Cas No.	705946-27-6
Smiles	CCN1CCC(CC1)Nc1ccc2NC(=O)\C(=C(/c3ncc(C)[nH]3)c3cccc(F)c3)c2c1
Relative Density.	1.280 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 62.5 mg/mL (140.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2445 mL	11.2226 mL	22.4452 mL	112.2259 mL
5 mM	0.4489 mL	2.2445 mL	4.4890 mL	22.4452 mL
10 mM	0.2245 mL	1.1223 mL	2.2445 mL	11.2226 mL
20 mM	0.1122 mL	0.5611 mL	1.1223 mL	5.6113 mL
50 mM	0.0449 mL	0.2245 mL	0.4489 mL	2.2445 mL
100 mM	0.0224 mL	0.1122 mL	0.2245 mL	1.1223 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc