drug-like — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2620	G-749	G749	Apoptosis , FLT , c-RET , TAM Receptor , Aurora Kinase
	G-749, a new-type FLT3 inhibitor, exhibits effective and sustained inhibition of the FLT3 wild type and mutants.		Apoptosis , FLT , c-RET , TAM Receptor , Aurora Kinase
T4697	ABBV-744	ABBV744	Epigenetic Reader Domain , HIV Protease
	ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2/3/4. It is used in the research on inflammatory diseases, cancer, and AIDS.		Epigenetic Reader Domain , HIV Protease
TP1215	Abaloparatide TFA	BA 058 TFA,Abaloparatide TFA (247062-33-5 free base),BIM 44058 TFA	Others
	Abaloparatide TFA (BIM 44058 TFA) is a parathyroid hormone-related protein (PTHrP) analog drug used to treat osteoporosis like the related drug teriparatide.		Others
T8395	Nomegestrol acetate		Others , Progesterone Receptor
	Nomegestrol acetate is a widely used progestin-like drug,which is characterized as a full agonist at the progesterone receptor		Others , Progesterone Receptor
T9623	RORγt inverse agonist 13		ROR
	RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].		ROR
T2641	KRCA-0008	KRCA 0008,KRCA0008	ACK , ALK
	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.		ACK , ALK
T21673	N-Isopropylnoratropine		Others
	N-Isopropylnoratropine is a noratropine derivative and an intermediate in the production of ipratropium, an atropine-like bronchodilator drug via an anticholinergic pathway. N-Isopropylnoratropine is used to examine the ...		Others
T64374	QN523		Autophagy
	QN523 represents a novel scaffold with drug-like properties, showing potent in vitro cytotoxicity in a panel of 12 cancer cell lines. QN523 shows significant in vivo efficacy in a pancreatic cancer xenograft model. Autop...		Autophagy
T0383	Fenspiride hydrochloride	Fenspiride HCl,Pneumorel,Fluiden,Decaspiride	Adrenergic Receptor , PDE , Histamine Receptor
	Fenspiride hydrochloride (Decaspiride) , an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use in Russia for the therapy of chronic and acute inflammatory ...		Adrenergic Receptor , PDE , Histamine Receptor
T2940	6-Hydroxyflavone	6-HF	GABA Receptor
	6-Hydroxyflavone (6-HF) is a noncompetitive inhibitors of cytochrome P450 2C9. It is a flavone, a type of chemical compound. It is reported in leaves of Barleria prionitis Linn. (a common Acanthaceae from India). 6-Hydro...		GABA Receptor
T8873	Bractoppin		Others , DNA/RNA Synthesis
	Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activi...		Others , DNA/RNA Synthesis
T2836	Isorhamnetin	3-methylquercetin,3'-Methylquercetin,Isorhamnetol,3'-Methoxyquercetin	MEK , PI3K , Endogenous Metabolite
	Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents endothelial cell injuries from oxidized LD...		MEK , PI3K , Endogenous Metabolite
T4978	Sarpogrelate hydrochloride	MCI-9042	5-HT Receptor
	Sarpogrelate hydrochloride (MCI-9042) , a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. Target: 5-HT2 Recepter Sarpogrelate is a drug which acts as an antagonist at ...		5-HT Receptor
T16857	SB269652		Others
	SB269652 is the first drug-like allosteric modulator of the dopamine D2 receptor.		Others
T24886	TIQ-15	TIQ 15,TIQ15
	TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.
T25151	Bibrocathol	Bibrocathin,Bibrocatholum
	Bibrocathol is a well-established antiseptic drug used for the treatment of acute eyelid diseases like blepharitis.
T70007	CT-179
	CT-179 is a highly potent and selective small molecule inhibitor of Olig2 with excellent drug-like properties.
T29065	UNC9994	UNC-9994,UNC 9994
	UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.
T18313	Mc-O-Si(di-iso)-Cl		Others
	Mc-O-Si(di-iso)-Cl is a cleavable ADC linker, commonly employed in the synthesis of antibody-drug conjugates (ADCs) like Gemcitabine-O-Si(di-iso)-O-Mc [1].		Others
T69613	Ar-H047108 free base
	Ar-H047108 free base is an imidazopyridine potassium competitive acid blocker (P-CAB). This drug may be used to treat early stellate cell activation and veno-occlusive-disease (VOD)-like hepatotoxicity.