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Fenspiride hydrochloride

Catalog No. T0383 CAS 5053-08-7

Synonyms: Fenspiride HCl, Pneumorel, Fluiden, Decaspiride

Fenspiride hydrochloride (Decaspiride) , an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use in Russia for the therapy of chronic and acute inflammatory diseases of ENT organs and the respiratory tract (like sinusitis, tracheobronchitis, otitis, laryngitis, and rhinopharyngitis), and for maintenance therapy of asthma.

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Fenspiride hydrochloride Chemical Structure

Fenspiride hydrochloride, CAS 5053-08-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 33.00
50 mg	In stock	$ 46.00
100 mg	In stock	$ 67.00
200 mg	In stock	$ 98.00
500 mg	In stock	$ 158.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.78%

Purity: 99.18%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fenspiride hydrochloride (Decaspiride) , an oxazolidinone spiro compound, is a drug used in the therapy of certain respiratory diseases. It is approved for use in Russia for the therapy of chronic and acute inflammatory diseases of ENT organs and the respiratory tract (like sinusitis, tracheobronchitis, otitis, laryngitis, and rhinopharyngitis), and for maintenance therapy of asthma.
Targets&IC50	PDE3:3.44(pIC50), PDE4:4.16(pIC50)
In vitro	Fenspiride induces potentiation of the effects of isoprenaline and sodium nitroprusside with logEC50 of 4.1 and 3.5, respectively, in human isolated bronchi. [1]
In vivo	Fenspiride, an antiinflammatory drug with low anti-cyclooxygenase activity, administered orally at 60-200 mg/kg inhibits neutrophil migration into peritoneal and air pouches cavities as well as exudation into peritoneal cavities induced by endotoxin but not induced by carrageenin in the rat. Fenspiride (200 mg/kg) inhibits the release of tumour necrosis factor by stimulated macrophages in a dose-dependent manner in the rat. [2] Fenspiride (Topically applied) is found to inhibit the development of sclerotic lesions in myringotomized rats, whereas intraperitoneal injections are ineffective. [3] Fenspiride (60 mg/kg) significantly reduces the lipopolysaccharide-induced early rise of tumor necrosis factor concentrations in serum (4.2 ng/mL vs. 2.3 ng/mL) and in the bronchoalveolar lavage fluid (55.7 ng/mL vs. 19.7 ng/mL) of guinea-pigs with endotoxemia. Fenspiride (60 mg/kg) also significantly reduces the lipopolysaccharide-induced primed stimulation of alveolar macrophages, defined as their enhanced release of arachidonic acid metabolites as compared to cells from untreated controls upon stimulation with N-formyl-methionyl-phenylalanine. Fenspiride (60 mg/kg) reduces the increased serum concentrations of extracellular type II phospholipase A2, the intensity of the neutrophilic alveolar invasion and the lethality due to the lipopolysaccharide in guinea-pigs with endotoxemia. [4]

Synonyms	Fenspiride HCl, Pneumorel, Fluiden, Decaspiride
Molecular Weight	296.79
Formula	C15H20N2O2·HCl
CAS No.	5053-08-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9 mg/mL (30.32 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 54 mg/mL (181.9 mM)

References and Literature

1. Cortijo J, et al. Eur J Pharmacol, 1998, 341(1), 79-86. 2. Cunha FQ, et al. Eur J Pharmacol, 1993, 238(1), 47-52. 3. Mattsson C, et al. Eur Arch Otorhinolaryngol, 1997, 254(9-10), 425-429. 4. De Castro CM, et al. Eur J Pharmacol, 1995, 294(2-3), 669-676.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Approved Drug Library GPCR Compound Library FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Drug-Fragment Library Neurotransmitter Receptor Compound Library

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Keywords

Fenspiride hydrochloride 5053-08-7 GPCR/G Protein Immunology/Inflammation Metabolism Neuroscience Adrenergic Receptor PDE Histamine Receptor Phosphodiesterase (PDE) Inhibitor orally active Fenspiride non-steroidal antiinflammatory Fenspiride HCl Pneumorel Fluiden inhibit Decaspiride guinea-pigs Fenspiride Hydrochloride respiratory diseases inhibitor

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