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Search Result

Search Results for " ca-i "

Targets

Carbonic Anhydrase

28

Compounds

7

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T36758 CAIX Inhibitor S4 S4 Carbonic Anhydrase
CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM.
T2134 Dorzolamide hydrochloride MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,Dorzolamide HCl Carbonic Anhydrase
Dorzolamide hydrochloride (MK507 hydrochloride) is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water ...
T68123 Oxodipine Calcium Channel
Oxodipine, a dihydropyridine-type calcium antagonist , inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventri...
T20000 I-XW-053 HIV Protease
I-XW-053 is a capsid targeted HIV-1 replication inhibitor.
T6503 Fluorometholone Acetate NSC 47438,Flarex,Eflone,Oxylone acetate Glucocorticoid Receptor , Carbonic Anhydrase
Fluorometholone Acetate (Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
T61745 HCAI/II-IN-6 Carbonic Anhydrase
hCAI/II-IN-6 is a selective and orally active inhibitor of human carbonic anhydrase (CA). hCAI/II-IN-6 inhibited hCA I, hCA II, hCA VII, and hCA XII with Ki values of 220, 4.9, 6.5, and ＞50,000 nM. hCAI/II-IN-6 showed an...
T23782 Benzolamide CL-11366,W 1803,CL 11366,CL11366,W-1803 Carbonic Anhydrase
Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.
T0515 Tioxolone Carbonic Anhydrase
Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.
T40376 L-Phenylalanine-15N (S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N Calcium Channel
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) is the 15N-labeled L-Phenylalanine. L-Phenylalanine is an essential amino acid isolated from Escherichia coli . L-Phenylalanine is a α2δ subunit of voltage-dep...
T0106 Methazolamide L584601,CL 8490 Carbonic Anhydrase
Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
T72122 Carbonic anhydrase inhibitor 12 Carbonic Anhydrase
Carbonic Anhydrase Inhibitor 12 is a potent inhibitor of CA II, with additional inhibitory activity against CA I, exhibiting K_i values of 1.72 nM for CA II and 271 nM for CA I. Moreover, it demonstrates significant anti...
T74978 DPP IV/hCA II-IN-1
DPP IV/hCA II-IN-1 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA), exhibiting an IC50 of 0.049 μM for DPP IV and K_i values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and...
T73030 HCAIX-IN-14
hCAIX-IN-14 is a potent inhibitor of human CA IX with a K i value of 134.8 nM .
T72840 HCAIX/XII-IN-6
hCAIX/XII-IN-6, an orally active carbonic anhydrase (CA) inhibitor, targets human CA isoforms hCA I, II, IV, IX, and XII with inhibition constants (K i) of 6697 nM, 2950 nM, 4093 nM, 4.1 nM, and 7.7 nM, respectively. Thi...
T40895 Calmodulin antagonist-1
Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treat...
T79753 HCAIX/XII-IN-8 Carbonic Anhydrase
hCAIX/XII-IN-8 (compound 3g) is a potent inhibitor of the human carbonic anhydrases (CAs) IX and XII, with inhibition constants (K i) of 8.5 nM for CA IX and 6.7 nM for CA XII. It demonstrates significant inhibitory effi...
T61842 Carbonic anhydrase inhibitor 14
Carbonic anhydrase inhibitor 14 (Compound 8b) is a potent CA inhibitor, exhibiting K i values of 1203, 99.7, 9.4, and 27.7 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. Additionally, it effectively inhibit...
T71223 SR-33805
SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting ...
T60602 HCAIX/XII-IN-5
hCAIX/XII-IN-5 (Coumarin 9a) is an inhibitor of carbonic anhydrase (CA) that shows excellent hCA IX/XII selectivity with Kis of 93.3 and 85.7 nM over hCA I and hCA II, respectively. hCAIX/XII-IN-5 has anti-proliferative ...
T76184 Scyllatoxin
Scyllatoxin (Leiurotoxin I), a peptide toxin derived from the venom of the scorpion (Leiurus quinquestriatus hebraeus), acts as a blocker of small-conductance K Ca (SK) channels. It notably enhances the release of norepi...
T75936 RVD-Hpα TFA
RVD-Hpα TFA is the N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist. RVD-Hpα TFA increases intracellular Ca 2+ levels in cells expressing CB1 receptors in vitro. RVD-Hpα TFA a...
T72213 Efonidipine hydrochloride NZ-105 hydrochloride
Efonidipine HCl (NZ-105) serves as both a T-type and L-type calcium channel blocker. This compound, distinct from other calcium channel blockers, notably increases N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate...
T72700 Cavα2δ1&NET-IN-2
Cavα2δ1&NET-IN-2 . Cavα2δ1&NET-IN-2 inhibits Ca v α2δ-1 with a K i of 454 nM. Cavα2δ1&NET-IN-2 inhibits NET with a K i of 59 nM and IC 50 of 7 nM. Cavα2δ1&NET-IN-2 can be used for research of pain .
T72699 Cavα2δ1&NET-IN-1
Cavα2δ1&NET-IN-1 . Cavα2δ1&NET-IN-1 inhibits Ca v α2δ-1 with a K i of 112 nM. Cavα2δ1&NET-IN-1 inhibits NET with a K i of 383 nM and IC 50 of 67 nM. Cavα2δ1&NET-IN-1 can be used for research of pain .
T62243 Bepridil hydrochloride hydrate
Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a long-acting, non-selective antagonist of the calcium channel (Ca+channel), Bepridil hydrochloride hydrate is an inhibitor of the Na+,K+channel and ...
T76021 Myelin Basic Protein TFA
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide containing residues 4-14 of myelin basic protein, serves as a highly selective substrate for protein kinase C (PKC) with a K_m of 7 μM. It is not phosphorylated by ...
T37847 Zonisamide-13C2,15N Zonisamide-13C2,15N
Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels ...
T69383 NBI-42902
NBI-42902 is a potent inhibitor of peptide radioligand binding to the human GnRH receptor (K(i) = 0.56 nm). Tritiated NBI-42902 binds with high affinity (K(d) = 0.19 nm) to a single class of binding sites and can be disp...

Compounds

CAIX Inhibitor S4
T36758
Synonym: S4
Target: Carbonic Anhydrase
Dorzolamide hydrochloride
T2134
Synonym: MK507 hydrochloride,L671152 hydrochloride,MK-507 (L-671152) HCl,Dorzolamide HCl
Target: Carbonic Anhydrase
Oxodipine
T68123
Synonym:
Target: Calcium Channel
I-XW-053
T20000
Synonym:
Target: HIV Protease
Fluorometholone Acetate
T6503
Synonym: NSC 47438,Flarex,Eflone,Oxylone acetate
Target: Glucocorticoid Receptor, Carbonic Anhydrase
hCAI/II-IN-6
T61745
Synonym:
Target: Carbonic Anhydrase
Benzolamide
T23782
Synonym: CL-11366,W 1803,CL 11366,CL11366,W-1803
Target: Carbonic Anhydrase
Tioxolone
T0515
Synonym:
Target: Carbonic Anhydrase
L-Phenylalanine-15N
T40376
Synonym: (S)-2-Amino-3-phenylpropionic acid-15N,L-Phenylalanine-15N
Target: Calcium Channel
Methazolamide
T0106
Synonym: L584601,CL 8490
Target: Carbonic Anhydrase
Carbonic anhydrase inhibitor 12
T72122
Synonym:
Target: Carbonic Anhydrase
DPP IV/hCA II-IN-1
T74978
Synonym:
Target:
hCAIX-IN-14
T73030
Synonym:
Target:
hCAIX/XII-IN-6
T72840
Synonym:
Target:
Calmodulin antagonist-1
T40895
Synonym:
Target:
hCAIX/XII-IN-8
T79753
Synonym:
Target: Carbonic Anhydrase
Carbonic anhydrase inhibitor 14
T61842
Synonym:
Target:
SR-33805
T71223
Synonym:
Target:
hCAIX/XII-IN-5
T60602
Synonym:
Target:
Scyllatoxin
T76184
Synonym:
Target:
RVD-Hpα TFA
T75936
Synonym:
Target:
Efonidipine hydrochloride
T72213
Synonym: NZ-105 hydrochloride
Target:
Cavα2δ1&NET-IN-2
T72700
Synonym:
Target:
Cavα2δ1&NET-IN-1
T72699
Synonym:
Target:
Bepridil hydrochloride hydrate
T62243
Synonym:
Target:
Myelin Basic Protein TFA
T76021
Synonym:
Target:
Zonisamide-13C2,15N
T37847
Synonym: Zonisamide-13C2,15N
Target:
NBI-42902
T69383
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T6856 Halofuginone Tempostatin,empostatin,RU-19110 Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
T3524 Halofuginone hydrobromide Tempostatin,RU-19110 (hydrobromide),Stenorol Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
T4S2326 Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside ERK , p38 MAPK , NF-κB , JNK
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...
T3826 Polygalasaponin F NF-κB , TLR , Akt , PI3K
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...
TN3844 Didrovaltrate Calcium Channel
Didrovaltrate shows cytotoxic against human cancer cell lines. Didrovaltrate blocks I(Ca-L) in a concentration-dependent manner and probably inhibits I(Ca-L) in its inactive state, which may contribute to its cardiovascu...
TN2039 Panaxydol cAMP , p38 MAPK , JNK
Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through ...
TN6458 Acetylshikonin
Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acety...

Natural Products

Halofuginone
T6856
Synonym: Tempostatin,empostatin,RU-19110
Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Halofuginone hydrobromide
T3524
Synonym: Tempostatin,RU-19110 (hydrobromide),Stenorol
Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad
Cornuside
T4S2326
Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside
Target: ERK, p38 MAPK, NF-κB, JNK
Polygalasaponin F
T3826
Synonym:
Target: NF-κB, TLR, Akt, PI3K
Didrovaltrate
TN3844
Synonym:
Target: Calcium Channel
Panaxydol
TN2039
Synonym:
Target: cAMP, p38 MAPK, JNK
Acetylshikonin
TN6458
Synonym:
Target:

Recombinant Proteins

Species：
Human (3)
Rat (1)
Expression System：
E. coli (4)
Tag：
His (2)
C-6xHis (1)
N-6xHis-SUMO (1)
Cat No. Product Name Species Expression System
TMPJ-00731 Carbonic Anhydrase 1 Protein, Human, Recombinant (His) Human E. coli
Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly expressed in erythrocytes and acts as an early marker for erythroid differentiation. Carbonic anhydrase 1 p...
TMPH-03258 Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) Rat E. coli
Reversible hydration of carbon dioxide. Carbonic Anhydrase 1 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.2 kDa and the acce...
TMPY-01926 S100A10 Protein, Human, Recombinant (His) Human E. coli
S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name is derived from the fact that...
TMPY-02289 CIB2 Protein, Human, Recombinant (His) Human E. coli
Calcium and integrin-binding protein 2 (CIB2) belongs to a protein family with four known members, CIB1 through CIB4, which are characterized by multiple calcium-binding EF-hand domains. Sensorineural hearing loss is gen...
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