blk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T26817	Bim-BLK-A	Bim Blocker A,Compound A,Bim BLK A,BimBLKA
	Bim-BLK-A efficiently blocks Bim-induced apoptosis after Bax is activated on the mitochondria. The cellular target of Bim-BLK-A was identified to be the succinate dehydrogenase subunit B (SDHB) protein of complex II of t...
T63959	BLK-IN-1
	BLK-IN-1 is a selective, covalent inhibitor of B-lymphotyrosine kinase (BLK) and BTK with IC50 values of 18.8 nM and 20.5 nM, respectively. BLK-IN-1 can be used in cancer research.
T73366	BLK-IN-2
	BLK-IN-2 is a potent, selective, and irreversible inhibitor of B-Lymphoid tyrosine kinase (BLK), demonstrating significant efficacy with an IC50 of 5.9 nM. Additionally, it exhibits an inhibitory effect on BTK (Bruton's ...
T9072	Tuxobertinib	BDTX-189	EGFR , HER , BTK , RIP kinase
	Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively). BDTX-189 exhibits anticancer activ...		EGFR , HER , BTK , RIP kinase
T6078	Saracatinib	AZD0530	EGFR , Src , BTK , Autophagy
	Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.		EGFR , Src , BTK , Autophagy
T14692	BMX-IN-1	BMX kinase inhibitor	BTK
	BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 ...		BTK
T71819	RK-20448
	RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259
T39129	BMS-986143
	BMS-986143, an orally active, reversible BTK inhibitor with an IC50 value of 0.26 nM, is designed for autoimmune disease research. Additionally, it targets TEC, BLK, BMX, TXK, FGR, YES1, and ITK, exhibiting IC50s of 3 nM...
T74642	DB1113
	DB1113 (Example 24) is a bifunctional compound designed for the targeted degradation of various kinases. It effectively degrades a range of kinases, including ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, M...
T7819	TAS0728		EGFR , HER
	TAS0728 is a HER2 inhibitor, with antitumor activity		EGFR , HER
T5138	BMS-986142		BTK
	BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).		BTK
T10802	CHMFL-EGFR-202		EGFR
	CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase (IC50s: 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases).		EGFR
T74644	DB0614
	DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down a wide array of kinases including AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK...
T12542	Rilzabrutinib	PRN1008	EGFR , Others , HER , BTK
	Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).		EGFR , Others , HER , BTK
T1835	Ibrutinib	PCI-32765	Tyrosine Kinases , Src , BTK , Ligands for Target Protein for PROTAC
	Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
T13564L	AZ7550 hydrochloride	AZ7550 hydrochloride (1421373-99-0 free base)	EGFR , IGF-1R
	AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).		EGFR , IGF-1R
T13564	AZ7550		MLK , FAK , EGFR , FLT , Tyrosine Kinases , PYK2 , MNK , IGF-1R , ACK , BTK , ALK , Drug Metabolite
	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T16578	PRN694		Others
	PRN694 shows extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo. PRN694 is an irreversible, highly selective, and effective covalent interleukin-2-inducible...		Others
T10801	CHMFL-ABL/KIT-155	CHMFL-ABL-KIT-155	c-Kit
	CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis.		c-Kit
T18049	Ibrutinib-biotin		Others
	Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, has an IC50 of 0.755-1.02 nM for BTK.		Others

Compounds

Bim-BLK-A

T26817

Synonym: Bim Blocker A,Compound A,Bim BLK A,BimBLKA

Target: EGFR, HER, BTK, RIP kinase

Saracatinib

T6078

Synonym: AZD0530

Target: EGFR, Src, BTK, Autophagy

BMX-IN-1

T14692

Synonym: BMX kinase inhibitor

Target: EGFR, Others, HER, BTK

Ibrutinib

T1835

Synonym: PCI-32765

Target: Tyrosine Kinases, Src, BTK, Ligands for Target Protein for PROTAC

AZ7550 hydrochloride

T13564L

Synonym: AZ7550 hydrochloride (1421373-99-0 free base)

Target: MLK, FAK, EGFR, FLT, Tyrosine Kinases, PYK2, MNK, IGF-1R, ACK, BTK, ALK, Drug Metabolite

Synonym: CHMFL-ABL-KIT-155

Cat No.	Product Name	Species	Expression System
TMPJ-00307	BLK Protein, Human, Recombinant (His)	Human	E. coli
	Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling...
TMPY-04388	BLK Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organ...

Cat No.

Product Name

Species

Expression System

TMPJ-00307

BLK Protein, Human, Recombinant (His)

Human

E. coli

Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling...

TMPY-04388

BLK Protein, Human, Recombinant (GST)

Human

Baculovirus Insect Cells

Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organ...

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Compounds

Recombinant Proteins

Compounds

Recombinant Proteins