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BMX-IN-1

Catalog No. T14692   CAS 1431525-23-3
Synonyms: BMX kinase inhibitor

BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.

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BMX-IN-1 Chemical Structure
BMX-IN-1, CAS 1431525-23-3
Pack Size Availability Price/USD Quantity
1 mg In stock $ 48.00
2 mg In stock $ 72.00
5 mg In stock $ 139.00
10 mg In stock $ 247.00
25 mg In stock $ 417.00
50 mg In stock $ 619.00
100 mg In stock $ 879.00
1 mL * 10 mM (in DMSO) In stock $ 158.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
Targets&IC50 BTK:10.4 nM, Bmx:8 nM
In vitro BMX-IN-1 inhibits only wild-type BMX with an IC50 of 138 nM. BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 cells and RV-1 cells with IC50s of 25 nM and 2.53 μM. BMX-IN-1 exhibits remarkable selectivity with an S(10) score of 0.01[1].
Synonyms BMX kinase inhibitor
Molecular Weight 524.59
Formula C29H24N4O4S
CAS No. 1431525-23-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 9 mg/mL (17.16 mM), sonification is recommended.

DMSO: 8 mg/mL (15.25 mM), sonification is recommended.

TargetMolReferences and Literature

1. Feiyang Liu, et al. Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer. ACS Chem. Biol.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Bioactive Compound Library Kinase Inhibitor Library Inhibitor Library Covalent Inhibitor Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets
GDC-0834 JAK3/BTK-IN-1 BTK-IN-16 Tuxobertinib LFM-A13 ACP-5862 BMS-986142 BTK inhibitor 1

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Keywords

BMX-IN-1 1431525-23-3 Angiogenesis Tyrosine Kinase/Adaptors BTK BMX kinase inhibitor inhibit BMX Kinase BMX IN 1 Bruton tyrosine kinase Btk Inhibitor BMXIN1 inhibitor

 

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