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BMX-IN-1

Catalog No. T14692 CAS 1431525-23-3

Synonyms: BMX kinase inhibitor

BMX-IN-1 is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (<a href="/target/BTK" style="display: inline; color: #c13a36">BTK</a>, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, <a href="/target/JAK" style="display: inline; color: #c13a36">JAK</a>3, <a href="/target/EGFR" style="display: inline; color: #c13a36">EGFR</a>, Itk, or Tec activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BMX-IN-1, CAS 1431525-23-3

Pack Size	Availability	Price/USD
2 mg	In stock	$ 86.00
5 mg	In stock	$ 158.00
10 mg	In stock	$ 275.00
25 mg	In stock	$ 417.00
50 mg	In stock	$ 677.00
100 mg	In stock	$ 938.00
200 mg	In stock	$ 1,397.00
500 mg	In stock	$ 2,673.00
1 mL * 10 mM (in DMSO)	In stock	$ 181.00

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Purity: 98%

Biological Description

Chemical Properties

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Description	BMX-IN-1 is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
Targets&IC50	BTK:10.4 nM, Bmx:8 nM
In vitro	BMX-IN-1 inhibits only wild-type BMX with an IC50 of 138 nM. BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 cells and RV-1 cells with IC50s of 25 nM and 2.53 μM. BMX-IN-1 exhibits remarkable selectivity with an S(10) score of 0.01[1].

Synonyms	BMX kinase inhibitor
Molecular Weight	524.59
Formula	C29H24N4O4S
CAS No.	1431525-23-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMF: 9 mg/mL (17.16 mM), Need ultrasonic

DMSO: 8 mg/mL (15.25 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Feiyang Liu, et al. Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer. ACS Chem. Biol. 1. Feiyang Liu , et al. Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer. ACS Chem. Biol., DOI: 10.1021/cb4000629

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max Kinase Inhibitor Library Inhibitor Library

Related Products

Related compounds with same targets

(±)-Zanubrutinib JAK3/BTK-IN-1 Acalabrutinib enantiomer AS-1763 BTK inhibitor 1 (Compound 27) Naluzotan CHMFL-BTK-01 Spebrutinib besylate

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMX-IN-1 1431525-23-3 Angiogenesis Tyrosine Kinase/Adaptors BTK inhibit BMX Kinase BMX IN 1 Bruton tyrosine kinase Btk Inhibitor BMX kinase inhibitor BMXIN1 inhibitor

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