Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
2 mg | In stock | $ 72.00 | |
5 mg | In stock | $ 139.00 | |
10 mg | In stock | $ 247.00 | |
25 mg | In stock | $ 417.00 | |
50 mg | In stock | $ 619.00 | |
100 mg | In stock | $ 879.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 158.00 |
Description | BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity. |
Targets&IC50 | BTK:10.4 nM, Bmx:8 nM |
In vitro | BMX-IN-1 inhibits only wild-type BMX with an IC50 of 138 nM. BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 cells and RV-1 cells with IC50s of 25 nM and 2.53 μM. BMX-IN-1 exhibits remarkable selectivity with an S(10) score of 0.01[1]. |
Synonyms | BMX kinase inhibitor |
Molecular Weight | 524.59 |
Formula | C29H24N4O4S |
CAS No. | 1431525-23-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 9 mg/mL (17.16 mM), sonification is recommended.
DMSO: 8 mg/mL (15.25 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BMX-IN-1 1431525-23-3 Angiogenesis Tyrosine Kinase/Adaptors BTK BMX kinase inhibitor inhibit BMX Kinase BMX IN 1 Bruton tyrosine kinase Btk Inhibitor BMXIN1 inhibitor