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Ibrutinib-biotin

Catalog No. T18049 CAS 1599432-18-4

Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, has an IC50 of 0.755-1.02 nM for BTK.

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Ibrutinib-biotin, CAS 1599432-18-4

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ibrutinib-biotin is a probe that consists of Ibrutinib linked to biotin via a long chain linker, has an IC50 of 0.755-1.02 nM for BTK.
Targets&IC50	BLK:3.66-4.27 nM (IC50), BTK:0.755-1.02 nM (IC50), JAK3:5.34-4.87 μM (IC50), BMX:4.42-5.57 nM (IC50), ITK:0.187-0.198 μM (IC50), TEC:1.71-2.29 nM (IC50), Lck:5.99-6.92 nM (IC50), Src:33.8-36.3 nM (IC50)
In vitro	Ibrutinib-biotin (Compound 1-5) is a probe composed of Ibrutinib, a TEC family kinase inhibitor, connected to biotin through a long-chain linker. The TEC family includes five kinases: TEC, BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX, and TXK/RLK, which are involved in phosphotyrosine- and phospholipid-mediated signaling pathways. These kinases, notably prevalent in hematopoietic tissues, are crucial for the proliferation and differentiation of blood cells[1].

Molecular Weight	1097.39
Formula	C56H80N12O9S
CAS No.	1599432-18-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (45.56 mM), Sonication is recommended.

References and Literature

1. Betty Y. CHANG, et al. Companion diagnostics for tec family kinase inhibitor therapy. WO 2014059368 A1.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ibrutinib-biotin 1599432-18-4 Others Ibrutinibbiotin Ibrutinib biotin inhibitor inhibit

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