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Rilzabrutinib

Catalog No. T12542   CAS 1575596-29-0
Synonyms: PRN1008

Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).

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Rilzabrutinib Chemical Structure
Rilzabrutinib, CAS 1575596-29-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 118.00
5 mg In stock $ 287.00
10 mg In stock $ 457.00
25 mg In stock $ 753.00
50 mg In stock $ 1,060.00
100 mg In stock $ 1,430.00
1 mL * 10 mM (in DMSO) In stock $ 426.00
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Purity: 99.76%
Purity: 97.87%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Rilzabrutinib (PRN1008) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK)(IC50 of 1.3 nM).
Targets&IC50 RLK:1.2 nM, EGFR:520 nM, BLK:6.3 nM, BTK:1.3 nM, ErbB4:11.3 nM, Bmx:1.0 nM, Itk:440 nM, TEC:0.8 nM, ErbB2:3900 nM
Synonyms PRN1008
Molecular Weight 665.76
Formula C36H40FN9O3
CAS No. 1575596-29-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 130 mg/mL (195.27 mM)

TargetMolReferences and Literature

1. Smith PF, et al. A phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton's tyrosine kinase, in healthy volunteers. Br J Clin Pharmacol. 2017 Nov;83(11):2367-2376. 2. Hill RJ, Bradshaw JM, Bisconte A, Tam D, Owens TD, Brameld KA, Smith PF, Funk JO, Goldstein DM, Nunn PA. Preclinical Characterization of PRN1008, a Novel Reversible Covalent Inhibitor of BTK that Shows Efficacy in a RAT Model of Collagen-Induced Arthritis. Annals of the Rheumatic Diseases 2015; 74(Suppl 2): 216.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Tyrosine Kinase Inhibitor Library Anti-Cancer Drug Library Anti-Lung Cancer Compound Library Anti-Pancreatic Cancer Compound Library Covalent Inhibitor Library Clinical Compound Library Cytokine Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets
Furanodienone Cisapride AG-1478 PD-118057 AG1557 Zongertinib BMS-599626 PF04929113

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Keywords

Rilzabrutinib 1575596-29-0 Angiogenesis JAK/STAT signaling Others Tyrosine Kinase/Adaptors EGFR BTK HER inhibit PRN-1008 PRN 1008 Inhibitor Btk PRN1008 Bruton tyrosine kinase inhibitor

 

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