Home Tools
Log in
Products Inhibitors Libraries Recombinant Proteins Kits Services Contact Us
Cart
Peptides Monoclonal Antibodies Dye Reagents PROTAC Virtual Screening TargetMol Kits Cell Counting Kit-8 (CCK-8) Inhibitor Cocktails Natural Products Phenols Alkaloids Flavonoids
Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK
Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
Fragment Libraries General Fragment Libraries Characteristic Fragment Libraries Custom Compound Library
TargetMol
Cytokines and Growth Factors •   Cytokines •   Growth Factors Receptor Proteins •   Fc Receptors •   Cytokines and Growth Factor Receptors
CD Proteins •   T Cell CD Proteins •   B Cell CD Proteins Immune Checkpoint Proteins •   Co-inhibitory Immune Checkpoint Proteins •   Co-stimulatory Immune Checkpoint Proteins
CAR-T Therapy Target Proteins •   Hematologic Malignancies Target Proteins •   Solid Tumors Target Proteins Enzymes •   Oxidoreductases,EC 1 •   Transferases,EC 2
Viral Proteins •   Coronavirus (CoV) Proteins •   Influenza Proteins Fluorescent Proteins Others

Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Species：
Canine (9)
Cynomolgus (37)
Cynomolyus (1)
Human (136)
Mouse (64)
Rabbit (2)
Rat (27)
Rhesus (21)
Rhesus macaque (5)
Expression System：
Baculovirus-Insect Cells (2)
E. coli (3)
HEK293 (244)
Human Cells (35)
Tag：
AVI (32)
C-6His (12)
C-6His-Avi (2)
C-Avi-6His (2)
C-Fc (6)
C-Fc-6His (4)
C-Fc-Avi (1)
C-His (9)
C-His-Avi (19)
C-hFc (4)
C-hFc-Avi (2)
C-mFc (1)
Fc (1)
His (98)
N-10His (1)
N-6His (3)
N-6His-Avi (1)
N-6His-Flag (2)
N-8His (1)
N-His (4)
N-His-Avi (2)
N-His-Flag (2)
N-monomeric hFc (1)
None (2)
Tag Free (5)
hFc (82)
mFc (12)
rFc (8)
Cat No. product name / Synonyms Species Expression System
TMPK-00260 CD155/PVR Protein, Human, Recombinant (His & Avi)
CD155/PVR Protein, Human, Recombinant (His & Avi)
 Human HEK293
CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tum...
TMPK-00280 B7-H6 Protein, Human, Recombinant (His & Avi), Biotinylated
B7-H6 Protein, Human, Recombinant (His & Avi), Biotinylated
 Human HEK293
B7-H6 is a glycosylated member of the B7 family of immune co‑stimulatory proteins. which is a ligand for the NK cell activating receptor NKp30, was targeted to c...
TMPK-00314 B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
 Human HEK293
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-00315 B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
 Human HEK293
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-00463 OX40/TNFRSF4/CD134 Protein, Mouse, Recombinant (His & Avi)
OX40/TNFRSF4/CD134 Protein, Mouse, Recombinant (His & Avi)
 Mouse HEK293
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec...
TMPK-00464 OX40/TNFRSF4/CD134 Protein, Mouse, Recombinant (His & Avi), Biotinylated
OX40/TNFRSF4/CD134 Protein, Mouse, Recombinant (His & Avi), Biotinylated
 Mouse HEK293
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec...
TMPK-00653 B7-2/CD86 Protein, Cynomolgus, Recombinant (His)
B7-2/CD86 Protein, Cynomolgus, Recombinant (His)
 Cynomolgus HEK293
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-00666 CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His)
CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His)
 Cynomolgus HEK293
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7.  CD70 is a...
TMPK-00860 CD40 Ligand/TNFSF5 Trimer Protein, Mouse, Recombinant (monomeric hFc)
CD40 Ligand/TNFSF5 Trimer Protein, Mouse, Recombinant (monomeric hFc)
 Mouse HEK293
CD40 ligand or CD40L, also called CD154,  is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It b...
TMPK-00880 B7-2/CD86 Protein, Human, Recombinant (His & Avi)
B7-2/CD86 Protein, Human, Recombinant (His & Avi)
 Human HEK293
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-00881 B7-2/CD86 Protein, Human, Recombinant (His & Avi), Biotinylated
B7-2/CD86 Protein, Human, Recombinant (His & Avi), Biotinylated
 Human HEK293
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-00882 B7-2/CD86 Protein, Human, Recombinant (hFc)
B7-2/CD86 Protein, Human, Recombinant (hFc)
 Human HEK293
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
TMPK-01016 B7-H3/CD276 Protein, Human, Recombinant (hFc), FITC-Labeled
B7-H3/CD276 Protein, Human, Recombinant (hFc), FITC-Labeled
 Human HEK293
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-01017 B7-H3/CD276 Protein, Human, Recombinant (hFc)
B7-H3/CD276 Protein, Human, Recombinant (hFc)
 Human HEK293
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-01018 B7-H3/CD276 Protein, Human, Recombinant (His)
B7-H3/CD276 Protein, Human, Recombinant (His)
 Human HEK293
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
TMPK-01086 GITR/TNFRSF18 Protein, Mouse, Recombinant (His)
GITR/TNFRSF18 Protein, Mouse, Recombinant (His)
 Mouse HEK293
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune re...
TMPK-01176 CD28 Protein, Canine, Recombinant (His)
CD28 Protein, Canine, Recombinant (His)
 Canine HEK293
CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen present...
TMPK-01177 CD28 Protein, Canine, Recombinant (mFc)
CD28 Protein, Canine, Recombinant (mFc)
 Canine HEK293
CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen present...
TMPK-01260 GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (His)
GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (His)
 Cynomolgus HEK293
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune re...
TMPY-00004 CD28 Protein, Rat, Recombinant (hFc)
CD28 Protein, Rat, Recombinant (hFc)
 Rat HEK293
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ...
CD155/PVR Protein, Human, Recombinant (His & Avi)
TMPK-00260
CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tum...
B7-H6 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00280
B7-H6 is a glycosylated member of the B7 family of immune co‑stimulatory proteins. which is a ligand for the NK cell activating receptor NKp30, was targeted to c...
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
TMPK-00314
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00315
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
OX40/TNFRSF4/CD134 Protein, Mouse, Recombinant (His & Avi)
TMPK-00463
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec...
OX40/TNFRSF4/CD134 Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPK-00464
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec...
B7-2/CD86 Protein, Cynomolgus, Recombinant (His)
TMPK-00653
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
CD27 Ligand/CD70 Protein, Cynomolgus, Recombinant (His)
TMPK-00666
CD70, also named CD27 ligand (CD27L), is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF7.  CD70 is a...
CD40 Ligand/TNFSF5 Trimer Protein, Mouse, Recombinant (monomeric hFc)
TMPK-00860
CD40 ligand or CD40L, also called CD154,  is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It b...
B7-2/CD86 Protein, Human, Recombinant (His & Avi)
TMPK-00880
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
B7-2/CD86 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00881
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
B7-2/CD86 Protein, Human, Recombinant (hFc)
TMPK-00882
B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimul...
B7-H3/CD276 Protein, Human, Recombinant (hFc), FITC-Labeled
TMPK-01016
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
B7-H3/CD276 Protein, Human, Recombinant (hFc)
TMPK-01017
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
B7-H3/CD276 Protein, Human, Recombinant (His)
TMPK-01018
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet ...
GITR/TNFRSF18 Protein, Mouse, Recombinant (His)
TMPK-01086
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune re...
CD28 Protein, Canine, Recombinant (His)
TMPK-01176
CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen present...
CD28 Protein, Canine, Recombinant (mFc)
TMPK-01177
CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen present...
GITR/TNFRSF18 Protein, Cynomolgus, Recombinant (His)
TMPK-01260
GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune re...
CD28 Protein, Rat, Recombinant (hFc)
TMPY-00004
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ...
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
CORPORATE
About Us Careers Privacy Notice Events & News Terms & Conditions
SUPPORT
Contact Us Worldwide Distributors Quality Control Technical Support
RESOURCE
Product Catalog Product Citations Signaling Pathways Solution Calculators
FOLLOW OUR
Social Network
Newsletter Subscription
Subscribe to receive our lastest product updates and special offers!
Corporate
Support
Resource
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
TargetMol
Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved.