Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.
Cat No. | product name / Synonyms | Species | Expression System |
---|---|---|---|
TMPY-05597 | CD155/PVR Protein, Mouse, Recombinant (hFc & AVI), Biotinylated
CD155/PVR Protein, Mouse, Recombinant (hFc & AVI), Biotinylated
|
Mouse | HEK293 |
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne... | |||
TMPY-05599 | CD40 Protein, Human, Recombinant (hFc & AVI), Biotinylated
CD40 Protein, Human, Recombinant (hFc & AVI), Biotinylated
|
Human | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r... | |||
TMPY-05614 | CD40 Protein, Human, Recombinant (His & AVI), Biotinylated
CD40 Protein, Human, Recombinant (His & AVI), Biotinylated
|
Human | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r... | |||
TMPY-05638 | CD200 Protein, Human, Recombinant (hFc & AVI)
CD200 Protein, Human, Recombinant (hFc & AVI)
|
Human | HEK293 |
CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expre... | |||
TMPY-05645 | ICOS Protein, Rhesus, Recombinant (hFc & AVI), Biotinylated
ICOS Protein, Rhesus, Recombinant (hFc & AVI), Biotinylated
|
Rhesus | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa... | |||
TMPY-05646 | CD40 Ligand Protein, Human, Recombinant (hFc & AVI), Biotinylated
CD40 Ligand Protein, Human, Recombinant (hFc & AVI), Biotinylated
|
Human | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-05651 | ICOS Protein, Mouse, Recombinant (hFc & AVI), Biotinylated
ICOS Protein, Mouse, Recombinant (hFc & AVI), Biotinylated
|
Mouse | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa... | |||
TMPY-05652 | CD28 Protein, Mouse, Recombinant (His), Biotinylated
CD28 Protein, Mouse, Recombinant (His), Biotinylated
|
Mouse | HEK293 |
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ... | |||
TMPY-05770 | ILDR2 Protein, Human, Recombinant (hFc)
ILDR2 Protein, Human, Recombinant (hFc)
|
Human | HEK293 |
TMPY-05790 | CD27 Protein, Mouse, Recombinant (mFc)
CD27 Protein, Mouse, Recombinant (mFc)
|
Mouse | HEK293 |
CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t... | |||
TMPY-05791 | CD155/PVR Protein, Mouse, Recombinant (mFc)
CD155/PVR Protein, Mouse, Recombinant (mFc)
|
Mouse | HEK293 |
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne... | |||
TMPY-05811 | B7-1 Protein, Mouse, Recombinant (His), Biotinylated
B7-1 Protein, Mouse, Recombinant (His), Biotinylated
|
Mouse | HEK293 |
The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ... | |||
TMPY-05819 | 4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (AVI & Fc), Biotinylated
4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (AVI & Fc), Biotinylated
|
Human | HEK293 |
4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfam... | |||
TMPY-06018 | OX40L/TNFSF4 Protein, Mouse, Recombinant (His)
OX40L/TNFSF4 Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecul... | |||
TMPY-06024 | CD40 Protein, Mouse, Recombinant (His & AVI), Biotinylated
CD40 Protein, Mouse, Recombinant (His & AVI), Biotinylated
|
Mouse | HEK293 |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r... | |||
TMPY-06133 | CD155/PVR Protein, Human, Recombinant (hFc & AVI), Biotinylated
CD155/PVR Protein, Human, Recombinant (hFc & AVI), Biotinylated
|
Human | HEK293 |
CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne... | |||
TMPY-06178 | B7-H6 Protein, Human, Recombinant (His), Biotinylated
B7-H6 Protein, Human, Recombinant (His), Biotinylated
|
Human | HEK293 |
TMPY-06184 | CD48 Protein, Mouse, Recombinant (His), Biotinylated
CD48 Protein, Mouse, Recombinant (His), Biotinylated
|
Mouse | HEK293 |
Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami... | |||
TMPY-06192 | CD226 Protein, Cynomolgus, Recombinant (His)
CD226 Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 |
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified... | |||
TMPY-06209 | ICOS Protein, Mouse, Recombinant (His)
ICOS Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 |
Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa... |