Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

Cat No.	product name / Synonyms	Species	Expression System
TMPY-00036	CD28 Protein, Cynomolgus, Recombinant (hFc) CD28 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
TMPY-00036	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ...
TMPY-00037	B7-1 Protein, Rat, Recombinant (hFc) B7-1 Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-00037	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-00070	CD226 Protein, Rat, Recombinant (His) CD226 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-00070	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-00213	ICOS ligand Protein, Rat, Recombinant (His) ICOS ligand Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-00213	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb...
TMPY-00230	4-1BB/CD137 Protein, Canine, Recombinant (hFc) 4-1BB/CD137 Protein, Canine, Recombinant (hFc)	Canine	HEK293
TMPY-00230	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-00268	B7-H3 Protein, Cynomolgus, Recombinant (hFc) B7-H3 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
TMPY-00268	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-00327	B7-H6 Protein, Rat, Recombinant (hFc) B7-H6 Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-00327
TMPY-00329	ICOS ligand Protein, Cynomolgus, Recombinant (His) ICOS ligand Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
TMPY-00329	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb...
TMPY-00377	B7-H6 Protein, Human, Recombinant (hFc) B7-H6 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-00377
TMPY-00482	CD40 Protein, Human, Recombinant (hFc) CD40 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-00482	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-00643	B7-H3 Protein, Human, Recombinant (hFc) B7-H3 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-00643	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-00656	2B4/CD244 Protein, Human, Recombinant (hFc) 2B4/CD244 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-00656	The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of...
TMPY-00712	CD48 Protein, Human, Recombinant (His) CD48 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-00712	Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami...
TMPY-00762	CD155/PVR Protein, Mouse, Recombinant (His) CD155/PVR Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-00762	CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne...
TMPY-00959	4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (His) 4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-00959	4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfam...
TMPY-00965	ICOS ligand Protein, Mouse, Recombinant (His & hFc) ICOS ligand Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
TMPY-00965	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb...
TMPY-01063	B7-1 Protein, Human, Recombinant (His) B7-1 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01063	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-01071	CD200 Protein, Human, Recombinant (His) CD200 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01071	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expre...
TMPY-01160	CD200 Protein, Mouse, Recombinant (His) CD200 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-01160	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expre...
TMPY-01177	CD226 Protein, Mouse, Recombinant (His) CD226 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-01177	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified...