Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

Cat No.	product name / Synonyms	Species	Expression System
TMPY-06831	4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc) 4-1BB Ligand/TNFSF9 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-06831	4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfam...
TMPY-06875	OX40 Protein, Human, Recombinant (hFc & AVI), Biotinylated OX40 Protein, Human, Recombinant (hFc & AVI), Biotinylated	Human	HEK293
TMPY-06875	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex...
TMPY-06880	CD86 Protein, Human, Recombinant (His & AVI), Biotinylated CD86 Protein, Human, Recombinant (His & AVI), Biotinylated	Human	HEK293
TMPY-06880	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-06906	OX40 Protein, Human, Recombinant (His & AVI), Biotinylated OX40 Protein, Human, Recombinant (His & AVI), Biotinylated	Human	HEK293
TMPY-06906	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex...
TMPY-06909	B7-1 Protein, Rat, Recombinant (His) B7-1 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-06909	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-06953	CD70 Protein, Human, Recombinant (His) CD70 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-06953	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept...
TMPY-06979	ICOS Protein, Human, Recombinant (His) ICOS Protein, Human, Recombinant (His)	Human	HEK293
TMPY-06979	Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa...
TMPJ-00103	CD28 Protein, Human/Cynomolgus, Recombinant (His) CD28 Protein, Human/Cynomolgus, Recombinant (His)	Human,Cynomolgus	Human Cells
TMPJ-00103	T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belon...
TMPJ-00139	4-1BBL Protein, Human, Recombinant (His) 4-1BBL Protein, Human, Recombinant (His)	Human	E. coli
TMPJ-00139	Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1B...
TMPY-00033	4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (hFc) 4-1BB Ligand/TNFSF9 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-00033	4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfam...
TMPY-00674	B7-1 Protein, Human, Recombinant B7-1 Protein, Human, Recombinant	Human	HEK293
TMPY-00674	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-00699	CD155/PVR Protein, Human, Recombinant (hFc) CD155/PVR Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-00699	CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne...
TMPY-01068	CD70 Protein, Human, Recombinant (hFc) CD70 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-01068	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept...
TMPY-01152	CD226 Protein, Human, Recombinant (His) CD226 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01152	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-01180	CD86 Protein, Human, Recombinant (His) CD86 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01180	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-01181	CD40 Protein, Human, Recombinant (His) CD40 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01181	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-01386	CD155/PVR Protein, Human, Recombinant (His) CD155/PVR Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01386	CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne...
TMPY-01423	OX40 Protein, Human, Recombinant (His) OX40 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01423	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex...
TMPY-01612	CD155/PVR Protein, Rhesus, Recombinant (His) CD155/PVR Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
TMPY-01612	CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne...
TMPY-01672	ICOS ligand Protein, Human, Recombinant (His) ICOS ligand Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01672	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb...