Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

Cat No.	product name / Synonyms	Species	Expression System
TMPY-03944	CD40 Protein, Canine, Recombinant CD40 Protein, Canine, Recombinant	Canine	HEK293
TMPY-03944	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-04019	BTN3A3 Protein, Human, Recombinant (mFc) BTN3A3 Protein, Human, Recombinant (mFc)	Human	HEK293
TMPY-04019	The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the...
TMPY-04065	CD40 Ligand Protein, Canine, Recombinant (mFc) CD40 Ligand Protein, Canine, Recombinant (mFc)	Canine	HEK293
TMPY-04065	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-04086	CD40 Ligand Protein, Canine, Recombinant CD40 Ligand Protein, Canine, Recombinant	Canine	HEK293
TMPY-04086	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-04089	CD40 Protein, Canine, Recombinant (His) CD40 Protein, Canine, Recombinant (His)	Canine	HEK293
TMPY-04089	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-04208	CD48 Protein, Mouse, Recombinant (hFc) CD48 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-04208	Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami...
TMPY-04252	CD28 Protein, Rat, Recombinant (His) CD28 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-04252	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ...
TMPY-04279	B7-H3 Protein, Mouse, Recombinant (His), Biotinylated B7-H3 Protein, Mouse, Recombinant (His), Biotinylated	Mouse	HEK293
TMPY-04279	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-04284	B7-H3 Protein, Rat, Recombinant (His) B7-H3 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-04284	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-04349	B7-1 Protein, Cynomolgus, Rhesus, Recombinant (His) B7-1 Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
TMPY-04349	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-04350	ICOS ligand Protein, Mouse, Recombinant (His) ICOS ligand Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-04350	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb...
TMPY-04354	OX40L/TNFSF4 Protein, Human, Recombinant (mFc) OX40L/TNFSF4 Protein, Human, Recombinant (mFc)	Human	HEK293
TMPY-04354	OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecul...
TMPY-04495	B7-H6 Protein, Rat, Recombinant (His) B7-H6 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-04495
TMPY-04497	CD70 Protein, Mouse, Recombinant (mFc) CD70 Protein, Mouse, Recombinant (mFc)	Mouse	HEK293
TMPY-04497	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept...
TMPY-04585	B7-H3 Protein, Cynomolgus, Recombinant (His) B7-H3 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
TMPY-04585	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-04617	B7-H6 Protein, Cynomolgus, Recombinant (hFc) B7-H6 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
TMPY-04617
TMPY-04618	B7-H6 Protein, Cynomolgus, Recombinant (His) B7-H6 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
TMPY-04618
TMPY-04619	B7-H6 Protein, Human, Recombinant (His) B7-H6 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-04619
TMPY-04718	OX40 Protein, Rhesus, Recombinant (hFc) OX40 Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
TMPY-04718	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex...
TMPY-04719	4-1BB/CD137 Protein, Cynomolgus, Rhesus, Recombinant (hFc) 4-1BB/CD137 Protein, Cynomolgus, Rhesus, Recombinant (hFc)	Cynomolgus,Rhesus	HEK293
TMPY-04719	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...