Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

Cat No.	product name / Synonyms	Species	Expression System
TMPY-01206	CD86 Protein, Mouse, Recombinant (His) CD86 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-01206	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-01372	CD48 Protein, Mouse, Recombinant (His) CD48 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-01372	Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami...
TMPY-01378	CD27 Protein, Mouse, Recombinant (His & hFc) CD27 Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
TMPY-01378	CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t...
TMPY-01399	ICOS Protein, Human, Recombinant (His & hFc) ICOS Protein, Human, Recombinant (His & hFc)	Human	HEK293
TMPY-01399	Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa...
TMPY-01432	CD27 Protein, Mouse, Recombinant (His) CD27 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-01432	CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t...
TMPY-01568	2B4/CD244 Protein, Human, Recombinant (His) 2B4/CD244 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01568	The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of...
TMPY-01610	CD155/PVR Protein, Rat, Recombinant (His) CD155/PVR Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-01610	CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne...
TMPY-01758	CD40 Ligand Protein, Human, Recombinant (His) CD40 Ligand Protein, Human, Recombinant (His)	Human	E. coli
TMPY-01758	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-01955	CD28 Protein, Mouse, Recombinant (His) CD28 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-01955	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ...
TMPY-02016	CD86 Protein, Rat, Recombinant (His) CD86 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-02016	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-02307	B7-1 Protein, Mouse, Recombinant (His) B7-1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-02307	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-02330	4-1BB/CD137 Protein, Mouse, Recombinant (soluble form, hFc) 4-1BB/CD137 Protein, Mouse, Recombinant (soluble form, hFc)	Mouse	HEK293
TMPY-02330	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-02363	B7-1 Protein, Mouse, Recombinant (hFc) B7-1 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-02363	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-02368	OX40 Protein, Mouse, Recombinant (hFc) OX40 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-02368	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex...
TMPY-02793	CD40 Ligand Protein, Mouse, Recombinant (hFc) CD40 Ligand Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-02793	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-02992	4-1BB Ligand/TNFSF9 Protein, Rat, Recombinant (hFc) 4-1BB Ligand/TNFSF9 Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-02992	4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfam...
TMPY-02993	4-1BB Ligand/TNFSF9 Protein, Rat, Recombinant (His) 4-1BB Ligand/TNFSF9 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-02993	4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfam...
TMPY-03070	CD27 Protein, Human, Recombinant (rFc) CD27 Protein, Human, Recombinant (rFc)	Human	HEK293
TMPY-03070	CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t...
TMPY-03083	CD40 Protein, Rat, Recombinant (hFc) CD40 Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-03083	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-03089	CD48 Protein, Rat, Recombinant (His) CD48 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-03089	Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami...