Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

Cat No.	product name / Synonyms	Species	Expression System
TMPY-04720	4-1BB/CD137 Protein, Cynomolgus, Rhesus, Recombinant (His) 4-1BB/CD137 Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
TMPY-04720	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-04723	OX40 Protein, Rhesus, Recombinant (His) OX40 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
TMPY-04723	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex...
TMPY-04857	ICOS ligand Protein, Rat, Recombinant (hFc) ICOS ligand Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-04857	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb...
TMPY-04858	ICOS ligand Protein, Cynomolgus, Recombinant (hFc) ICOS ligand Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
TMPY-04858	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb...
TMPY-04977	CD70 Protein, Human, Recombinant (mFc) CD70 Protein, Human, Recombinant (mFc)	Human	HEK293
TMPY-04977	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept...
TMPY-04980	OX40L/TNFSF4 Protein, Mouse, Recombinant (rFc) OX40L/TNFSF4 Protein, Mouse, Recombinant (rFc)	Mouse	HEK293
TMPY-04980	OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecul...
TMPY-04981	OX40L/TNFSF4 Protein, Mouse, Recombinant (mFc) OX40L/TNFSF4 Protein, Mouse, Recombinant (mFc)	Mouse	HEK293
TMPY-04981	OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecul...
TMPY-04982	CD70 Protein, Human, Recombinant (rFc) CD70 Protein, Human, Recombinant (rFc)	Human	HEK293
TMPY-04982	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept...
TMPY-04991	ICOS Protein, Mouse, Recombinant (rFc) ICOS Protein, Mouse, Recombinant (rFc)	Mouse	HEK293
TMPY-04991	Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa...
TMPY-04993	OX40 Protein, Mouse, Recombinant (rFc) OX40 Protein, Mouse, Recombinant (rFc)	Mouse	HEK293
TMPY-04993	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex...
TMPY-04994	CD40 Protein, Mouse, Recombinant (rFc) CD40 Protein, Mouse, Recombinant (rFc)	Mouse	HEK293
TMPY-04994	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-04995	4-1BB/CD137 Protein, Mouse, Recombinant (soluble form, rFc) 4-1BB/CD137 Protein, Mouse, Recombinant (soluble form, rFc)	Mouse	HEK293
TMPY-04995	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-05020	OX40 Protein, Mouse, Recombinant OX40 Protein, Mouse, Recombinant	Mouse	HEK293
TMPY-05020	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex...
TMPY-05031	4-1BB/CD137 Protein, Mouse, Recombinant (soluble form, His) 4-1BB/CD137 Protein, Mouse, Recombinant (soluble form, His)	Mouse	HEK293
TMPY-05031	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-05042	CD27 Protein, Rat, Recombinant (mFc) CD27 Protein, Rat, Recombinant (mFc)	Rat	HEK293
TMPY-05042	CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t...
TMPY-05091	OX40 Protein, Rat, Recombinant (hFc) OX40 Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-05091	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex...
TMPY-05105	4-1BB/CD137 Protein, Human, Recombinant (His), Biotinylated 4-1BB/CD137 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
TMPY-05105	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-05133	CD86 Protein, Mouse, Recombinant (His), Biotinylated CD86 Protein, Mouse, Recombinant (His), Biotinylated	Mouse	HEK293
TMPY-05133	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-05171	CD27 Protein, Rat, Recombinant (hFc) CD27 Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-05171	CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t...
TMPY-05173	4-1BB Ligand/TNFSF9 Protein, Cynomolgus, Recombinant (hFc) 4-1BB Ligand/TNFSF9 Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	HEK293
TMPY-05173	4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfam...