Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

Cat No.	product name / Synonyms	Species	Expression System
TMPK-00087	ICOS/CD278 (C136S, C137S) Protein, Human, Recombinant (His) ICOS/CD278 (C136S, C137S) Protein, Human, Recombinant (His)	Human	HEK293
TMPK-00087	Inducible co-stimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) and CRP-1 (CD28-related protein-1), is a member of ...
TMPK-00110	CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi) CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi)	Human,Cynomolgus,Rhesus macaque	HEK293
TMPK-00110	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen present...
TMPK-00111	CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated CD28 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi), Biotinylated	Human,Cynomolgus,Rhesus macaque	HEK293
TMPK-00111	CD28 is the receptor for CD80 (B7-1) and CD86 (B7-2) proteins.When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen present...
TMPK-00132	GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated GITR/TNFRSF18 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPK-00132	GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune re...
TMPK-00133	GITR/TNFRSF18 Protein, Human, Recombinant (His) GITR/TNFRSF18 Protein, Human, Recombinant (His)	Human	HEK293
TMPK-00133	GITR (glucocorticoid-induced tumor necrosis factor receptor), also known as AITR and TNFRSF18, is a 40 kDa transmembrane glycoprotein that functions in immune re...
TMPK-00147	4-1BB/TNFRSF9 Protein, Human, Recombinant (hFc & Avi) 4-1BB/TNFRSF9 Protein, Human, Recombinant (hFc & Avi)	Human	HEK293
TMPK-00147	4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but ...
TMPK-00148	4-1BB/TNFRSF9 Protein, Human, Recombinant (hFc & Avi), Biotinylated 4-1BB/TNFRSF9 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human	HEK293
TMPK-00148	4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but ...
TMPK-00152	CD27/TNFRSF7 Protein, Cynomolgus, Recombinant (His) CD27/TNFRSF7 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
TMPK-00152	CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co‑stimulatory molecule that sup...
TMPK-00154	CD40 Ligand/TNFSF5 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated CD40 Ligand/TNFSF5 Trimer Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated	Human	HEK293
TMPK-00154	CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It b...
TMPK-00167	OX40/TNFRSF4/CD134 Protein, Human, Recombinant (His & Avi) OX40/TNFRSF4/CD134 Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00167	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec...
TMPK-00168	OX40/TNFRSF4/CD134 Protein, Human, Recombinant (His & Avi), Biotinylated OX40/TNFRSF4/CD134 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPK-00168	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec...
TMPK-00169	OX40/TNFRSF4/CD134 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated OX40/TNFRSF4/CD134 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated	Human	HEK293
TMPK-00169	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molec...
TMPK-00170	CD40/TNFRSF5 Protein, Human, Recombinant (His & Avi), Biotinylated CD40/TNFRSF5 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPK-00170	CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activate...
TMPK-00178	B7-1/CD80 Protein, Human, Recombinant (His & Avi) B7-1/CD80 Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00178	Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal ne...
TMPK-00179	B7-1/CD80 Protein, Human, Recombinant (His & Avi), Biotinylated B7-1/CD80 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPK-00179	Cluster of differentiation 80 (also CD80 and B7-1) is a protein found on dendritic cells, activated B cells and monocytes that provides a costimulatory signal ne...
TMPK-00192	B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi) B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00192	B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulat...
TMPK-00224	BTN3A2 Protein, Human, Recombinant (His & Avi) BTN3A2 Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00224	BTN3A2/BT3.2 butyrophilin mRNA expression by tumoral cells was previously identified as a prognostic factor in a small cohort of high grade serous epithelial ova...
TMPK-00229	DNAM-1/CD226 Protein, Human, Recombinant (His & Avi) DNAM-1/CD226 Protein, Human, Recombinant (His & Avi)	Human	HEK293
TMPK-00229	DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular...
TMPK-00230	DNAM-1/CD226 Protein, Human, Recombinant (His & Avi), Biotinylated DNAM-1/CD226 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPK-00230	DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular...
TMPK-00237	2B4/CD244/SLAMF4 Protein, Human, Recombinant (His & Avi), Biotinylated 2B4/CD244/SLAMF4 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
TMPK-00237	2B4 (CD244) is expressed by memory-phenotype CD8() T cells and all natural killer (NK) cells. The ligand for 2B4, CD48, is expressed on hematopoietic cells. 2B4 ...