Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

Cat No.	product name / Synonyms	Species	Expression System
TMPY-06279	4-1BB/CD137 Protein, Mouse, Recombinant (His), Biotinylated 4-1BB/CD137 Protein, Mouse, Recombinant (His), Biotinylated	Mouse	HEK293
TMPY-06279	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-06280	2B4/CD244 Protein, Human, Recombinant (hFc & AVI), Biotinylated 2B4/CD244 Protein, Human, Recombinant (hFc & AVI), Biotinylated	Human	HEK293
TMPY-06280	The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of...
TMPY-06283	CD48 Protein, Human, Recombinant (His & AVI), Biotinylated CD48 Protein, Human, Recombinant (His & AVI), Biotinylated	Human	HEK293
TMPY-06283	Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami...
TMPY-06294	2B4/CD244 Protein, Human, Recombinant (His & AVI), Biotinylated 2B4/CD244 Protein, Human, Recombinant (His & AVI), Biotinylated	Human	HEK293
TMPY-06294	The CD244 antigen, also known as 2B4, is a cell surface glycoprotein implicated in the regulation of natural killer and T lymphocyte function. 2B4 is a member of...
TMPY-06298	B7-1 Protein, Human, Recombinant (His & AVI), Biotinylated B7-1 Protein, Human, Recombinant (His & AVI), Biotinylated	Human	HEK293
TMPY-06298	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-06299	CD48 Protein, Human, Recombinant (hFc & AVI), Biotinylated CD48 Protein, Human, Recombinant (hFc & AVI), Biotinylated	Human	HEK293
TMPY-06299	Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami...
TMPY-06329	4-1BB/CD137 Protein, Mouse, Recombinant (aa 1-211,His & AVI), Biotinylated 4-1BB/CD137 Protein, Mouse, Recombinant (aa 1-211,His & AVI), Biotinylated	Mouse	HEK293
TMPY-06329	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-06363	B7-H6 Protein, Cynomolgus, Recombinant (His & AVI), Biotinylated B7-H6 Protein, Cynomolgus, Recombinant (His & AVI), Biotinylated	Cynomolgus	HEK293
TMPY-06363
TMPY-06374	CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (mFc) CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (mFc)	Human,Cynomolgus,Rhesus	HEK293
TMPY-06374	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ...
TMPY-06382	4-1BB/CD137 Protein, Human, Recombinant (His & AVI), Biotinylated 4-1BB/CD137 Protein, Human, Recombinant (His & AVI), Biotinylated	Human	HEK293
TMPY-06382	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-06528	4-1BB/CD137 Protein, Human, Recombinant (soluble CD137, His) 4-1BB/CD137 Protein, Human, Recombinant (soluble CD137, His)	Human	HEK293
TMPY-06528	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-06581	B7-H3 Protein, Human, Recombinant (isoform 2, His) B7-H3 Protein, Human, Recombinant (isoform 2, His)	Human	HEK293
TMPY-06581	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-06622	CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His & AVI), Biotinylated CD28 Protein, Human, Cynomolgus, Rhesus, Recombinant (His & AVI), Biotinylated	Human,Cynomolgus,Rhesus	HEK293
TMPY-06622	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ...
TMPY-06687	CD40 Ligand Protein, Mouse, Recombinant (His) CD40 Ligand Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-06687	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-06711	B7-1 Protein, Mouse, Recombinant (His & AVI), Biotinylated B7-1 Protein, Mouse, Recombinant (His & AVI), Biotinylated	Mouse	HEK293
TMPY-06711	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-06770	CD70 Protein, Mouse, Recombinant (His & AVI), Biotinylated CD70 Protein, Mouse, Recombinant (His & AVI), Biotinylated	Mouse	HEK293
TMPY-06770	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept...
TMPY-06790	CD70 Protein, Mouse, Recombinant (His) CD70 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-06790	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept...
TMPY-06791	CD200 Protein, Human, Recombinant (His & AVI), Biotinylated CD200 Protein, Human, Recombinant (His & AVI), Biotinylated	Human	HEK293
TMPY-06791	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expre...
TMPY-06794	4-1BB/CD137 Protein, Mouse, Recombinant (aa 1-187,His & AVI), Biotinylated 4-1BB/CD137 Protein, Mouse, Recombinant (aa 1-187,His & AVI), Biotinylated	Mouse	HEK293
TMPY-06794	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-06813	ICOS ligand Protein, Human, Recombinant ICOS ligand Protein, Human, Recombinant	Human	HEK293
TMPY-06813	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb...