Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

Cat No.	product name / Synonyms	Species	Expression System
TMPY-03129	CD70 Protein, Rat, Recombinant (hFc) CD70 Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-03129	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept...
TMPY-03159	CD70 Protein, Rat, Recombinant (His) CD70 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-03159	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept...
TMPY-03207	CD48 Protein, Rat, Recombinant (hFc) CD48 Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-03207	Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami...
TMPY-03211	CD40 Protein, Rhesus, Recombinant (hFc) CD40 Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
TMPY-03211	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-03212	CD40 Protein, Rhesus, Recombinant (His) CD40 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
TMPY-03212	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-03301	CD40 Ligand Protein, Rat, Recombinant (hFc) CD40 Ligand Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-03301	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-03311	ICOS Protein, Rat, Recombinant (hFc) ICOS Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-03311	Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa...
TMPY-03348	CD226 Protein, Rat, Recombinant (hFc) CD226 Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-03348	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-03373	CD27 Protein, Rhesus, Recombinant (hFc) CD27 Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
TMPY-03373	CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t...
TMPY-03380	CD200 Protein, Rhesus, Recombinant (hFc) CD200 Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
TMPY-03380	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expre...
TMPY-03525	ICOS ligand Protein, Human, Recombinant (hFc) ICOS ligand Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-03525	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb...
TMPY-03542	CD40 Ligand Protein, Rhesus, Recombinant (hFc) CD40 Ligand Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
TMPY-03542	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-03562	CD86 Protein, Cynomolgus, Rhesus, Recombinant (hFc) CD86 Protein, Cynomolgus, Rhesus, Recombinant (hFc)	Cynomolgus,Rhesus	HEK293
TMPY-03562	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-03595	CD200 Protein, Rhesus, Recombinant (His) CD200 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
TMPY-03595	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expre...
TMPY-03646	CD86 Protein, Cynomolgus, Rhesus, Recombinant (His) CD86 Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
TMPY-03646	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-03741	B7-1 Protein, Cynomolgus, Rhesus, Recombinant (hFc) B7-1 Protein, Cynomolgus, Rhesus, Recombinant (hFc)	Cynomolgus,Rhesus	HEK293
TMPY-03741	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-03773	4-1BB/CD137 Protein, Canine, Recombinant (His) 4-1BB/CD137 Protein, Canine, Recombinant (His)	Canine	HEK293
TMPY-03773	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-03875	OX40L/TNFSF4 Protein, Cynomolgus, Recombinant (mFc) OX40L/TNFSF4 Protein, Cynomolgus, Recombinant (mFc)	Cynomolgus	HEK293
TMPY-03875	OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecul...
TMPY-03907	CD40 Protein, Canine, Recombinant (hFc) CD40 Protein, Canine, Recombinant (hFc)	Canine	HEK293
TMPY-03907	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-03914	B7-H3 Protein, Rat, Recombinant (hFc) B7-H3 Protein, Rat, Recombinant (hFc)	Rat	HEK293
TMPY-03914	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...