Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

Cat No.	product name / Synonyms	Species	Expression System
TMPY-05174	ICOS Protein, Rhesus, Recombinant (hFc) ICOS Protein, Rhesus, Recombinant (hFc)	Rhesus	HEK293
TMPY-05174	Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa...
TMPY-05224	ICOS ligand Protein, Human, Recombinant (His), Biotinylated ICOS ligand Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
TMPY-05224	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmemb...
TMPY-05226	CD226 Protein, Human, Recombinant (His), Biotinylated CD226 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
TMPY-05226	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-05246	CD86 Protein, Human, Recombinant (His), Biotinylated CD86 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
TMPY-05246	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-05279	B7-H3 Protein, Human, Recombinant (hFc), Biotinylated B7-H3 Protein, Human, Recombinant (hFc), Biotinylated	Human	HEK293
TMPY-05279	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-05339	OX40 Protein, Human, Recombinant (hFc) OX40 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-05339	OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis factor receptor/tumor necrosis factor superfamily, is known to break an ex...
TMPY-05359	CD40 Protein, Human, Recombinant (mFc) CD40 Protein, Human, Recombinant (mFc)	Human	HEK293
TMPY-05359	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-05379	B7-1 Protein, Human, Recombinant (hFc) B7-1 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-05379	The B-lymphocyte activation antigen B7-1 (referred to as B7), also known as CD80, is a member of cell surface immunoglobulin superfamily and is expressed on the ...
TMPY-05386	CD86 Protein, Mouse, Recombinant (hFc) CD86 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-05386	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-05389	ICOS Protein, Human, Recombinant (hFc) ICOS Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-05389	Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa...
TMPY-05390	CD86 Protein, Human, Recombinant (hFc) CD86 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-05390	CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominan...
TMPY-05391	CD28 Protein, Mouse, Recombinant (hFc) CD28 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-05391	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ...
TMPY-05415	CD27 Protein, Human, Recombinant (hFc & AVI), Biotinylated CD27 Protein, Human, Recombinant (hFc & AVI), Biotinylated	Human	HEK293
TMPY-05415	CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t...
TMPY-05425	CD40 Protein, Mouse, Recombinant (hFc) CD40 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-05425	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-05433	B7-H3 Protein, Mouse, Recombinant (hFc) B7-H3 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-05433	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-05445	CD27 Protein, Human, Recombinant (hFc) CD27 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-05445	CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t...
TMPY-05487	CD226 Protein, Human, Recombinant (hFc) CD226 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-05487	The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-05506	4-1BB Ligand/TNFSF9 Protein, Cynomolgus, Recombinant (hFc), Biotinylated 4-1BB Ligand/TNFSF9 Protein, Cynomolgus, Recombinant (hFc), Biotinylated	Cynomolgus	HEK293
TMPY-05506	4-1BB ligand is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfam...
TMPY-05583	CD70 Protein, Human, Recombinant (hFc & AVI), Biotinylated CD70 Protein, Human, Recombinant (hFc & AVI), Biotinylated	Human	HEK293
TMPY-05583	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its recept...
TMPY-05596	CD155/PVR Protein, Human, Recombinant (His & AVI), Biotinylated CD155/PVR Protein, Human, Recombinant (His & AVI), Biotinylated	Human	HEK293
TMPY-05596	CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the ne...