Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

Cat No.	product name / Synonyms	Species	Expression System
TMPY-01743	4-1BB/CD137 Protein, Human, Recombinant (His) 4-1BB/CD137 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-01743	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-01941	CD28 Protein, Human, Recombinant (hFc) CD28 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-01941	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ...
TMPY-02022	CD40 Ligand Protein, Human, Recombinant (hFc) CD40 Ligand Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-02022	The cluster of differentiation (CD) system is commonly used as cell markers in immunophenotyping. Different kinds of cells in the immune system can be identified...
TMPY-02031	B7-H3 Protein, Human, Recombinant (His) B7-H3 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-02031	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-02473	ICOS Protein, Mouse, Recombinant (hFc) ICOS Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
TMPY-02473	Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa...
TMPY-03203	CD40 Protein, Rat, Recombinant (His) CD40 Protein, Rat, Recombinant (His)	Rat	HEK293
TMPY-03203	CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential r...
TMPY-03401	CD27 Protein, Human, Recombinant (His) CD27 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
TMPY-03401	CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t...
TMPY-03947	CD48 Protein, Human, Recombinant (hFc) CD48 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-03947	Cluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfami...
TMPY-03967	BTN3A3 Protein, Human, Recombinant (His) BTN3A3 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-03967	The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the...
TMPY-04064	B7-H3 Protein, Mouse, Recombinant (His) B7-H3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
TMPY-04064	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-04262	B7-H3 Protein, Human, Recombinant (His), Biotinylated B7-H3 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293
TMPY-04262	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an impor...
TMPY-04779	BTN3A2 Protein, Human, Recombinant (His) BTN3A2 Protein, Human, Recombinant (His)	Human	HEK293
TMPY-04779	The three butyrophilin BTN3A molecules, BTN3A1, BTN3A2, and BTN3A3, are members of the B7/butyrophilin-like group of Ig superfamily receptors, which modulate the...
TMPY-04832	OX40L/TNFSF4 Protein, Human, Recombinant (hFc) OX40L/TNFSF4 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-04832	OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecul...
TMPY-04951	CD27 Protein, Human, Recombinant (His), Biotinylated CD27 Protein, Human, Recombinant (His), Biotinylated	Human	Baculovirus-Insect Cells
TMPY-04951	CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on t...
TMPY-05156	ICOS Protein, Human, Recombinant (rFc) ICOS Protein, Human, Recombinant (rFc)	Human	HEK293
TMPY-05156	Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 fa...
TMPY-05354	CD28 Protein, Human, Recombinant (hFc & AVI), Biotinylated CD28 Protein, Human, Recombinant (hFc & AVI), Biotinylated	Human	HEK293
TMPY-05354	CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single ...
TMPY-05376	4-1BB/CD137 Protein, Human, Recombinant (hFc) 4-1BB/CD137 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-05376	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-05446	CD200 Protein, Human, Recombinant (hFc) CD200 Protein, Human, Recombinant (hFc)	Human	HEK293
TMPY-05446	CD200 (OX-2) is a cell surface glycoprotein that imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expre...
TMPY-05504	4-1BB/CD137 Protein, Rhesus, Recombinant (His), Biotinylated 4-1BB/CD137 Protein, Rhesus, Recombinant (His), Biotinylated	Rhesus	HEK293
TMPY-05504	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...
TMPY-05594	4-1BB/CD137 Protein, Human, Recombinant (hFc & AVI), Biotinylated 4-1BB/CD137 Protein, Human, Recombinant (hFc & AVI), Biotinylated	Human	HEK293
TMPY-05594	CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necro...