pharmacokinetic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1803	GNF-5	GNF 5	SARS-CoV , Bcr-Abl
	GNF-5 is a specific non-ATP competitive inhibitor of Bcr-Abl (IC50: 0.22±0.1 uM, Wild-type Abl). It is an analog of GNF-2 with improved pharmacokinetic properties.		SARS-CoV , Bcr-Abl
T13099	TC ASK 10		ASK , MAPK
	TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14 nM).		ASK , MAPK
T4989	Fosfomycin Tromethamine		Antibacterial , Antibiotic
	An antibiotic produced by Streptomyces fradiae.		Antibacterial , Antibiotic
T2397	Topiroxostat	FYX-051	P450 , ROS , Xanthine Oxidase
	Topiroxostat (FYX-051) is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.		P450 , ROS , Xanthine Oxidase
T3131	Fosfomycin calcium	Phosphomycin calcium salt,Fosmicin	Antibacterial , Antibiotic
	Fosfomycin calcium (Phosphomycin calcium salt) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis.		Antibacterial , Antibiotic
T8262	Fosfomycin sodium	Fosfomycin Disodium	Antibacterial , Antibiotic
	Fosfomycin sodium is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an e...		Antibacterial , Antibiotic
T9643	ZN-c3		Wee1
	ZN-c3 is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties.		Wee1
T34705	SR4554	SR 4554
	SR4554 is a fluorine-containing 2-nitroimidazole, designed as a hypoxia marker detectable with 19F magnetic resonance spectroscopy (MRS). SR-4554 has plasma pharmacokinetic and toxicity profiles suitable for use as a hyp...
T69757	PDDC inhibitor
	PDDC is the first nSMase2 inhibitor that possesses both favorable pharmacodynamics and pharmacokinetic (PK) parameters, including substantial oral bioavailability, brain penetration, and significant inhibition of exosome...
T37082	HS271		IRAK
	HS271 is a selective, highly potent and orally active IRAK4 inhibitor (IC50= 7.2 μM). HS271 shows excellent enzymatic and cellular activities, as well as excellent pharmacokinetic properties.		IRAK
T22338	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	GDC046	Others , JAK
	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.		Others , JAK
T19858	Brodimoprim		DHFR , Antibacterial
	Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR). Brodimoprim is also a long-acting broad-spectrum antibacterial agent characterized by a good pharmacokinetic profile.		DHFR , Antibacterial
T26252	PI3Kδ-IN-3	TC KHNS 11	PI3K
	PI3Kδ-IN-3 (TC KHNS 11) is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.		PI3K
TN1048	Cnidilin	Knidilin
	Cnidilin (Knidilin) is found in association with Angelica dahurica roots, has high BBB permeability and has pharmacokinetic potential in the treatment of CNS disorders.
T26969	CCT365623	CCT-365623,CCT 365623	Monoamine Oxidase
	CCT365623 is an orally bioavailable Lysyl Oxidase inhibitor with good anti-LOX potency, selectivity, pharmacokinetic properties, as well as anti-metastatic efficacy.		Monoamine Oxidase
T26863	BMS-929075	BMS 929075,BMS929075	HCV Protease
	BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity.		HCV Protease
T6100	Torin 2		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
	Torin 2(IC50=0.25 nM), a specific and effective mTOR inhibitor, is the 800-fold greater specific activity for mTOR than PI3K and improves pharmacokinetic properties. The EC50 of Torin 2 for ATM/ATR/DNA-PK inhibition is 2...		Apoptosis , ATM/ATR , DNA-PK , mTOR , Autophagy
T9642	ZW4864 free base		Wnt/beta-catenin
	ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 (free base) inhibits β catenin/BCL9 PPI with a K i value of 0.76 μM an...		Wnt/beta-catenin
T16679	Belzutifan	PT2977,MK-6482	HIF
	Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor,...		HIF
T63208	Aβ-IN-1		Gamma-secretase
	Aβ-IN-1 is a novel, potent and orally active γ-secretase modulator (GSM). Aβ-IN-1 potently reduced Aβ42 levels with an IC 50 value of 0.091 μM in cultured cells without inhibiting CYP3A4. Aβ-IN-1 shows a sustained pharma...		Gamma-secretase