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BMS-929075

Catalog No. T26863 CAS 1217338-97-0

Synonyms: BMS 929075, BMS929075

BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

BMS-929075, CAS 1217338-97-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 190.00
5 mg	In stock	$ 480.00
10 mg	In stock	$ 687.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,480.00
100 mg	In stock	$ 1,990.00
500 mg	In stock	$ 3,920.00
1 mL * 10 mM (in DMSO)	In stock	$ 598.00

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Purity: 97.95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity.
Targets&IC50	Huh-7 cells:60 µM(CC50), HepG2 cells:>12.5 µM(CC50)
In vitro	BMS-929075 (0-60 µM) showed cytotoxicity with CC50 values of 60, >12.5, and >50 µM for Huh-7, HepG2, and primary human hepatocytes, respectively.[1]
In vivo	BMS-929075 (i.v. 2 mg/kg; orally 6 mg/kg) showed good pharmacokinetic parameters with an oral bioavailability of 48% in rats.[1]

Synonyms	BMS 929075, BMS929075
Molecular Weight	538.54
Formula	C31H24F2N4O3
CAS No.	1217338-97-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (51.06 mM)

References and Literature

1. Yeung KS, et al. Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies. J Med Chem. 2017;60(10):4369-4385.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compounds Library Max Clinical Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-929075 1217338-97-0 Microbiology/Virology Proteases/Proteasome HCV Protease BMS 929075 BMS929075 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.