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BMS-929075

Name: BMS-929075
Brand: TargetMol
SKU: T26863
Price: 190 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T26863Cas No. 1217338-97-0

Alias BMS929075, BMS 929075

BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity.

BMS-929075

🥰Excellent

Purity: 99.01%

Catalog No. T26863Alias BMS929075, BMS 929075Cas No. 1217338-97-0

Pack Size	Price	Availability
1 mg	$190	In Stock
5 mg	$480	In Stock
10 mg	$687	In Stock
25 mg	$1,080	In Stock
50 mg	$1,480	In Stock
100 mg	$1,990	In Stock
500 mg	$3,920	In Stock
1 mL x 10 mM (in DMSO)	$598	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.01%

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COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity.
Targets&IC50	HepG2 cells:>12.5 µM(CC50), Huh-7 cells:60 µM(CC50)
In vitro	BMS-929075 (0-60 µM) exhibited cytotoxicity with CC50 values of 60 µM, >12.5 µM, and >50 µM in Huh-7 cells, HepG2 cells, and primary human hepatocytes, respectively. [1]
In vivo	BMS-929075 (i.v. 2 mg/kg; orally 6 mg/kg) showed good pharmacokinetic parameters with an oral bioavailability of 48% in rats.[1]
Synonyms	BMS929075, BMS 929075

Chemical Properties

Molecular Weight	538.54
Formula	C₃₁H₂₄F₂N₄O₃
Cas No.	1217338-97-0
Smiles	N(C(=O)C1=CC(=C(C)C=C1)C=2C(F)=C3C(C(NC)=O)=C(OC3=CC2)C4=CC=C(F)C=C4)C5(CC5)C=6N=CC=CN6
Relative Density.	1.41 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 27.5 mg/mL (51.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8569 mL	9.2844 mL	18.5687 mL	92.8436 mL
5 mM	0.3714 mL	1.8569 mL	3.7137 mL	18.5687 mL
10 mM	0.1857 mL	0.9284 mL	1.8569 mL	9.2844 mL
20 mM	0.0928 mL	0.4642 mL	0.9284 mL	4.6422 mL
50 mM	0.0371 mL	0.1857 mL	0.3714 mL	1.8569 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc