Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 89.00 | |
5 mg | In stock | $ 195.00 | |
10 mg | In stock | $ 296.00 | |
25 mg | In stock | $ 498.00 | |
50 mg | In stock | $ 725.00 | |
100 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 227.00 |
Description | TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1,IC50 = 14 nM). The IC50 value for ASK2 is 0.51 μM. |
Targets&IC50 | ASK2:0.51 μM, ASK1:14 nM |
In vitro | Streptozotocin (STZ)-induced JNK in INS-1 pancreatic β cells from 0.3 μM inhibited by TC ASK 10 (0-10 μM; 1 hour; INS-1 cells). Phosphorylation of p38 is also inhibited in a dosedependent manner. |
In vivo | In rats, Pharmacokinetic profiles are tested. TC ASK 10 (rat cassette doing at 0.1 mg/kg, iv and 1 mg/kg, po.) has a good oral bioavailability. The Cmax, Tmax and AUCpo,0-8h are 285.1 ng/mL, 1.67 h and 275.4 ng.h/mL, respectively for TC ASK 10. |
Molecular Weight | 432.35 |
Formula | C21H23Cl2N5O |
CAS No. | 1005775-56-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (231.29 mM)
You can also refer to dose conversion for different animals. More
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TC ASK 10 1005775-56-3 Apoptosis MAPK ASK ASK1 oral MAP3K bioavailability TC ASK-10 TC ASK10 Inhibitor pharmacokinetic JNK p38 inhibit selective MAP kinase kinase kinase, MEKK, MAPKKK Phosphorylation inhibitor