osteoblast — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T81593	Osteoblast-Adhesive Peptide
	Osteoblast-Adhesive Peptide, a polypeptide designed for biomaterials' chemical modification, enhances osteoblast adhesion, showing promise for use in dentistry and orthopedics [1] [2].
TN5888	Toddaculin		Others
	Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in...		Others
T2771	Orcinol glucoside	Sakakin	Antioxidant
	Orcinol glucoside (Sakakin) (OG), an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn, shows potent antioxidative and anxiolytic activities without sedative effects.		Antioxidant
T39508	KY-02327		Others
	KY-02327, a metabolically stabilized analog of KY-02061, serves as a potent inhibitor of the Dishevelled (Dvl)-CXXC5 interaction. This compound activates the Wnt/β-catenin pathway, thereby promoting osteoblast differenti...		Others
T7844	4-IPP	4-Iodo-6-phenylpyrimidine	Others
	4-IPP (4-Iodo-6-phenylpyrimidine) is an irreversible inhibitor of macrophage migration inhibitory factor (MIF)		Others
T16159	Muramyl dipeptide	MDP	NOD
	Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation...		NOD
T8550	NDMC101		Others , NF-κB , Proteasome
	NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.		Others , NF-κB , Proteasome
T2848	Osthole	Osthol,NSC 31868,Ostol	Apoptosis , HBV , Parasite , Histamine Receptor
	Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation.		Apoptosis , HBV , Parasite , Histamine Receptor
T1810	Purmorphamine	Shh Signaling Antagonist VI	Hedgehog/Smoothened , Smo , Autophagy
	Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation.		Hedgehog/Smoothened , Smo , Autophagy
T13768	(+)-Medicarpin		Estrogen/progestogen Receptor
	(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium flo...		Estrogen/progestogen Receptor
T3488	Tectorigenin	4',5,7-Trihydroxy-6-methoxyisoflavone,Tectorigenine	Apoptosis
	Tectorigenin (4',5,7-Trihydroxy-6-methoxyisoflavone) is an O-methylated isoflavone. Tectorigenin Promotes Osteoblast Differentiation and in vivo Bone Healing, but Suppresses Osteoclast Differentiation and in vivo Bone Re...		Apoptosis
T22767	ER 50891		Retinoid Receptor
	ER-50891 is a potent retinoic acid receptor alpha (RARα) antagonist. er-50891 reduces the inhibitory effect of allosteric retinoic acid and restores osteoblast differentiation induced by bone morphogenetic protein 2.		Retinoid Receptor
T3925	Astragaloside I	Cyclosieversioside B,Astrasieversianin IV	Wnt/beta-catenin
	Astragaloside I (Cyclosieversioside B) is a natural product isolated from Astragalus membranaceus. It can stimulate osteoblast differentiation through the Wnt/β-catenin signaling pathway and can be used to study osteogen...		Wnt/beta-catenin
T6S1559	Aurantio-obtusin		Others
	1. Biotransformation of glucoAurantio-obtusin towards Aurantio-obtusin increased the toxicity of irinotecan through increased inhibition of SN-38 glucuronidation. 2. Aurantio-obtusin, stimulated chemotactic migration of ...		Others
T11048L	DIPQUO hydrochloride	DIPQUO hydrochloride(1269365-82-3 Free base)	Phosphorylase
	DIPQUO hydrochloride is an activator of the bone marker alkaline phosphatase (ALP), with an EC50 of 6.27 μM in C2C12 cells. DIPQUO hydrochloride promotes mouse and human osteoblast differentiation via activation of p38 M...		Phosphorylase
TN1918	Medicarpin		Apoptosis , BCL , ROS , JNK
	Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of peak bone mass, and is devoid of uterine estrogenicity; in add...		Apoptosis , BCL , ROS , JNK
T60554	Schnurri-3 inhibitor-1		Others
	Schnurri-3 inhibitor-1, a potent inhibitor of schnurri-3, is an essential regulator of bone formation in adults that can be used in osteoporosis research. Schnurri-3 inhibitor-1 can inhibit Shn3 with EF1alpha promoter in...		Others
T10109	3-Carene	Delta-3-Carene	COX , Antifungal
	3-Carene（Delta-3-Carene） is a bicyclic monoterpene extracted from western larch and Douglas-fir that acts as a phytofungicide.3-Carene inhibits inflammatory infiltrates and COX-2 overexpression induced by nociceptive sti...		COX , Antifungal
TP1345	Kisspeptin-10, human (TFA)(374675-21-5,FREE)		GPR , Kisspeptin
	Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role i...		GPR , Kisspeptin
T3S2312	Poncirin	Isosakuranetin-7-neohesperidoside	Apoptosis , Others
	1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enha...		Apoptosis , Others