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Osthole

Catalog No. T2848 CAS 484-12-8

Synonyms: Osthol, NSC 31868, Ostol

Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation.

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Osthole, CAS 484-12-8

Pack Size	Availability	Price/USD
100 mg	In stock	$ 31.00
500 mg	In stock	$ 65.00
1 g	In stock	$ 97.00
5 g	In stock	$ 271.00
1 mL * 10 mM (in DMSO)	In stock	$ 51.00

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Purity: 99.93%

Purity: 99.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation.
In vitro	The LD50 values of Osthole in various animals have been determined as follows: in rats, it exceeds 125 mg/kg when administered intravenously (i.v.); in rabbits, it is over 35 mg/kg (i.v.); and in dogs, it surpasses 150 mg/kg (i.v.).
In vivo	Osthol, when introduced to pre-washed rabbit platelets, inhibits platelet aggregation and ATP release induced by ADP, arachidonic acid, platelet-activating factor (PAF), collagen, ionophore A23187, and thrombin. In human osteoblasts, osthol promotes cell differentiation through the bone morphogenetic protein-2 / p38 and extracellular signal-regulated kinase 1/2 pathways. Additionally, in cell cultures, osthol suppresses the secretion of the hepatitis B virus by enhancing the glycosylation of HBsAg.
Cell Research	Osthole is dissolved in 96% ethyl alcohol and then sterilized through a 0.22 μg/mL filter and stored at 4°C as stock solutions for later dilution[1]. Peripheral blood samples are collected from participants between 7.00 and 9.00 a.m. on the first study day and these are concentrated in grouping tubes with K3EDTA. Fresh PBMCs are then prepared. Isolated cells are seeded on 24-well plates at 1×106 per well with RPMI-1640 and supplemented with 1% heat inactivated human AB serum, 1% gentamicin and 0.25% PHA. Active reagents are added to each well after 24 h and pure medium formed the control for each substance. Cells are then harvested after a further three days[1].
Source	Natural Products > Apiaceae > Cnidium

Synonyms	Osthol, NSC 31868, Ostol
Molecular Weight	244.29
Formula	C15H16O3
CAS No.	484-12-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 46 mg/mL (188.3 mM)

DMSO: 46 mg/mL (188.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Ko FN, et al. Thromb Haemost, 1989, 62(3), 1996-1999. 2. Kuo PL, et al. J Pharmacol Exp Ther, 2005, 314(3), 1290-1299. 3. Huang RL, et al. Hepatology, 1996, 24(3), 508-515. 4. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway[J]. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494.

Citations

1. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494. 2. Qu Y, Sun X, Wei N, et al.Inhibition of cutaneous heat‐sensitive Ca2+‐permeable transient receptor potential vanilloid 3 channels alleviates UVB‐induced skin lesions in mice.The FASEB Journal.2023, 37(12): e23309. 3. Xu Y, Qu Y, Zhang C, et al.Selective inhibition of overactive warmth-sensitive Ca2+-permeable TRPV3 channels by antispasmodic agent flopropione for alleviation of skin inflammation.Journal of Biological Chemistry.2023: 105595. 4. Li S H, Li M Y, Yuan T T, et al.Osthole Activates the Cholinergic Anti‐Inflammatory Pathway via α7nAChR Upregulation to Alleviate Inflammatory Responses.Chemistry & Biodiversity.2024: e202400290.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Antiparasitic Natural Product Library Anti-Parasitic Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Anti-Infection Compound Library Anti-Obesity Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Inflammatory Traditional Chinese Medicine Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Osthole 484-12-8 Apoptosis GPCR/G Protein Immunology/Inflammation Microbiology/Virology Neuroscience Parasite HBV Histamine Receptor inhibit Inhibitor Osthol NSC 31868 Hepatitis B virus NSC-31868 Ostol NSC31868 inhibitor

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