store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation through a decreased RANKL/OPG ratio. Muramyl dipeptide directly increases osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2 .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 297.00 | |
25 mg | In stock | $ 549.00 | |
50 mg | In stock | $ 789.00 | |
100 mg | In stock | $ 1,080.00 | |
500 mg | 5 days | $ 2,190.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 213.00 |
Description | Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide indirectly decreases osteoclast differentiation through a decreased RANKL/OPG ratio. Muramyl dipeptide directly increases osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is an inducer of bone formation through the induction of Runx2 . |
In vitro | Muramyl dipeptide increases the protein expression of Runx2 in a dose-dependent manner (0.1-10 μg/mL; 24 hours)[1]. It also enhances the mRNA levels of Runx2 in a dose-dependent manner (0.1-10 μg/mL; 6 hours)[2]. Muramyl dipeptide indirectly attenuates osteoclast differentiation by reducing the RANKL/OPG ratio[2]. |
In vivo |
Muramyl dipeptide can be used for animal modeling to establish sepsis models. Muramyl dipeptide (1.25 mg/kg; intraperitoneal injection; twice) alleviates osteoporosis-induced bone loss[2]. |
Synonyms | MDP |
Molecular Weight | 492.48 |
Formula | C19H32N4O11 |
CAS No. | 53678-77-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (101.53 mM), sonification is recommended.
H2O: 20 mg/mL (40.61 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Muramyl dipeptide 53678-77-6 Immunology/Inflammation NF-Κb NOD MDP inhibitor inhibit