levels — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11660	Insulin levels modulator		COX
	Insulin level regulators can be used to treat diabetes.		COX
T21865	BC 11-38		PDE
	BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).		PDE
T3174	Taprenepag	CP-544326	Prostaglandin Receptor
	Taprenepag (CP-544326) (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle.		Prostaglandin Receptor
TQ0218	Deoxyandrographolide	14-deoxyandrographolide	IL Receptor , TNF
	Deoxyandrographolide (14-deoxyandrographolide) potentiates NGF-induced neurite outgrowth. Deoxyandrographolide suppresses the production of proinflammatory mediators TNF-α and IL-6.		IL Receptor , TNF
T23550	YM-750	YM 750	Acyltransferase
	YM-750 is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), with an IC50 value of 0.18 μM. ACAT is an enzyme that catalyzes the conversion of cholesterol and long-chain fatty-acyl-coenzyme A into cholest...		Acyltransferase
T4473	Ibiglustat	Venglustat,SAR402671,GZ402671	Transferase
	Ibiglustat (GZ402671) is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. Ibiglustat blocks the formation of glucosylceramide (GL-1), a key intermediate in the synthe...		Transferase
T7943	Fluphenazine decanoate		Dopamine Receptor
	Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.		Dopamine Receptor
T7180	Sultopride hydrochloride	LIN-1418 hydrochloride	Dopamine Receptor
	Sultopride hydrochloride (LIN-1418 hydrochloride) is a selective dopamine D2 and D3 receptor antagonist.		Dopamine Receptor
T8818	TC-G 1005		GPCR19
	TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.		GPCR19
T1871	GBR 12935 dihydrochloride	GBR12935,GBR-12935,GBR 12935	Dopamine Receptor
	GBR 12935 dihydrochloride (GBR 12935) can induce the increase of the extracellular levels of dopamine to basal levels.		Dopamine Receptor
T4058	R-IMPP		Others , Serine/threonin kinase
	R-IMPP is an inhibitor of PCSK9 translation. R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.		Others , Serine/threonin kinase
T14075	A-802715		IL Receptor
	A-802715 is a novel methylxanthine derivative that decreases the endogenous formation and blood levels of pro-inflammatory substances and increases the formation and blood levels of anti-inflammatory substances such as i...		IL Receptor
T39989L	JQKD82 trihydrochloride		Histone Demethylase
	JQKD82 trihydrochloride, a cell-permeable and selective inhibitor of KDM5, enhances H3K4me3 levels and is utilized in multiple myeloma research.		Histone Demethylase
T15549	Icosabutate		Others
	Icosabutate is a structurally engineered and orally active ω-3 polyunsaturated fatty acid. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persist...		Others
T64345	4-(Dimethylamino)phenol		Others
	4-(Dimethylamino)phenol enhances extracellular lactate dehydrogenase (LDH) levels without significant effects on gluconeogenesis. Only when the membrane becomes permeable to LDH does 4-(Dimethylamino)phenol reduce ATP co...		Others
T3631	PF-8380		PDE
	PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhib...		PDE
T5S2083	Puerarin 6''-O-Xyloside		Apoptosis , Caspase
	Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 an...		Apoptosis , Caspase
T5251	Phenylpyruvic acid	2-Oxo-3-phenylpropanoic acid,3-Phenylpyruvic acid	Others , Endogenous Metabolite
	Phenylpyruvic acid (3-Phenylpyruvic acid) is a keto-acid that is an intermediate or catabolic byproduct of phenylalanine metabolism. It has a slight honey-like odor. Levels of phenylpyruvate are normally very low in bloo...		Others , Endogenous Metabolite
T1928	Anacetrapib	MK-0859	CETP
	Anacetrapib (MK-0859) (MK0859) is an effective, specific, reversible rhCETP and mutant CETP(C13S) inhibitor (IC50: 7.9 nM and 11.8 nM). Anacetrapib reduces the transfer of cholesteryl ester from HDL to LDL and/or VLDL th...		CETP
T2S0410	Euphorbia factor L1	Euphorbiasteroid	Apoptosis , P-gp
	Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, ant...		Apoptosis , P-gp