Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 and Bax, and reduced levels Bcl-2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 155.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 293.00 | |
25 mg | In stock | $ 497.00 | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 247.00 |
Description | Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 and Bax, and reduced levels Bcl-2. |
In vivo | The in vivo animal study showed that POS significantly inhibited tumour growth in A549 cells (p?0.01). The POS has significant antitumour activities. The mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 and Bax, and reduced levels Bcl-2[1]. |
Animal Research | The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the cytotoxicity of POS (at 10, 20 and 40?μM) in vitro, and xenograft nude mice were established to evaluate the antitumour effect of POS (at 40?mg/kg/d) in vivo by 15 days intraperitoneal injection (ip). To explore its mechanism of action, flow cytometry was performed to determine the pro-apoptotic effect of POS (at 10, 20 and 40?μM). Subsequently, the expression of caspase-3, caspase-7, caspase-9, Bcl-2 and Bax in A549 cells were determined[1]. |
Source |
Molecular Weight | 548.49 |
Formula | C26H28O13 |
CAS No. | 114240-18-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (45.58 mM)
You can also refer to dose conversion for different animals. More
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Puerarin 6''-O-Xyloside 114240-18-5 Apoptosis Proteases/Proteasome Caspase Inhibitor Puerarin 6''OXyloside inhibit Puerarin 6'' O Xyloside inhibitor